Seroatlas · Human Serome Atlas

MRPL11

Large ribosomal subunit protein uL11m

Also known as: RM11_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y3B7
Gene: MRPL11
Ensembl: ENSG00000174547
Chromosome: 11
Canonical length: 192 aa
Protein class: Predicted intracellular proteins, Ribosomal proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

This nuclear gene encodes a 39S subunit component of the mitochondial ribosome. Alternative splicing results in multiple transcript variants. Pseudogenes for this gene are found on chromosomes 5 and 12. [provided by RefSeq, May 2014]

Canonical amino-acid sequenceUniProt

192 residues, UniProt reviewed canonical sequence.

>Q9Y3B7|MRPL11
     1  MSKLGRAARG LRKPEVGGVI RAIVRAGLAM PGPPLGPVLG QRGVSINQFC KEFNERTKDI
    61  KEGIPLPTKI LVKPDRTFEI KIGQPTVSYF LKAAAGIEKG ARQTGKEVAG LVTLKHVYEI
   121  ARIKAQDEAF ALQDVPLSSV VRSIIGSARS LGIRVVKDLS SEELAAFQKE RAIFLAAQKE
   181  ADLAAQEEAA KK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MRPL11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 46 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 46 nTPM
tongue: 34 nTPM
rectum: 22 nTPM
bone marrow: 22 nTPM
ovary: 22 nTPM
liver: 21 nTPM

Single-cell type

esophageal basal cells: 259 nCPM
migrating cytotrophoblasts: 219 nCPM
extravillous trophoblasts: 217 nCPM
enteric transient amplifying cells: 179 nCPM
enteric stem cells: 165 nCPM
cytotrophoblasts: 160 nCPM

Immune cell

myeloid DC: 55 nTPM
memory B-cell: 52 nTPM
intermediate monocyte: 45 nTPM
T-reg: 44 nTPM
total PBMC: 43 nTPM
naive CD4 T-cell: 41 nTPM

Brain region

choroid plexus: 13 nTPM
thalamus: 13 nTPM
cerebral cortex: 12 nTPM
basal ganglia: 10 nTPM
cerebellum: 10 nTPM
medulla oblongata: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.88
gnomAD pLI: 0
gnomAD missense Z: -0.19
DepMap mean gene effect: -0.27
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MRPL11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MRPL11 as an antibody target. Whether an autoantibody or antibody against MRPL11 could matter depends on whether native MRPL11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MRPL11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MRPL11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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