Seroatlas · Human Serome Atlas

DIS3L

DIS3-like exonuclease 1

Also known as: DI3L1_HUMAN, DIS3L1, FLJ38088, KIAA1955, MGC4562

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TF46
Gene: DIS3L
Ensembl: ENSG00000166938
Chromosome: 15
Canonical length: 1054 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane,Centrosome,Basal body,Cytosol

OverviewNCBI Gene

The cytoplasmic RNA exosome complex degrades unstable mRNAs and is involved in the regular turnover of other mRNAs. The protein encoded by this gene contains 3'-5' exoribonuclease activity and is a catalytic component of this complex. [provided by RefSeq, May 2016]

Canonical amino-acid sequenceUniProt

1054 residues, UniProt reviewed canonical sequence.

>Q8TF46|DIS3L
     1  MLQKREKVLL LRTFQGRTLR IVREHYLRPC VPCHSPLCPQ PAACSHDGKL LSSDVTHYVI
    61  PDWKVVQDYL EILEFPELKG IIFMQTACQA VQHQRGRRQY NKLRNLLKDA RHDCILFANE
   121  FQQCCYLPRE RGESMEKWQT RSIYNAAVWY YHHCQDRMPI VMVTEDEEAI QQYGSETEGV
   181  FVITFKNYLD NFWPDLKAAH ELCDSILQSR RERENESQES HGKEYPEHLP LEVLEAGIKS
   241  GRYIQGILNV NKHRAQIEAF VRLQGASSKD SDLVSDILIH GMKARNRSIH GDVVVVELLP
   301  KNEWKGRTVA LCENDCDDKA SGESPSEPMP TGRVVGILQK NWRDYVVTFP SKEEVQSQGK
   361  NAQKILVTPW DYRIPKIRIS TQQAETLQDF RVVVRIDSWE STSVYPNGHF VRVLGRIGDL
   421  EGEIATILVE NSISVIPFSE AQMCEMPVNT PESPWKVSPE EEQKRKDLRK SHLVFSIDPK
   481  GCEDVDDTLS VRTLNNGNLE LGVHIADVTH FVAPNSYIDI EARTRATTYY LADRRYDMLP
   541  SVLSADLCSL LGGVDRYAVS IMWELDKASY EIKKVWYGRT IIRSAYKLFY EAAQELLDGN
   601  LSVVDDIPEF KDLDEKSRQA KLEELVWAIG KLTDIARHVR AKRDGCGALE LEGVEVCVQL
   661  DDKKNIHDLI PKQPLEVHET VAECMILANH WVAKKIWESF PHQALLRQHP PPHQEFFSEL
   721  RECAKAKGFF IDTRSNKTLA DSLDNANDPH DPIVNRLLRS MATQAMSNAL YFSTGSCAEE
   781  EFHHYGLALD KYTHFTSPIR RYSDIVVHRL LMAAISKDKK MEIKGNLFSN KDLEELCRHI
   841  NNRNQAAQHS QKQSTELFQC MYFKDKDPAT EERCISDGVI YSIRTNGVLL FIPRFGIKGA
   901  AYLKNKDGLV ISCGPDSCSE WKPGSLQRFQ NKITSTTTDG ESVTFHLFDH VTVRISIQAS
   961  RCHSDTIRLE IISNKPYKIP NTELIHQSSP LLKSELVKEV TKSVEEAQLA QEVKVNIIQE
  1021  EYQEYRQTKG RSLYTLLEEI RDLALLDVSN NYGI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DIS3L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 26 nTPM

Expression across tissuesHPA

Tissue

tongue: 26 nTPM
skeletal muscle: 19 nTPM
parathyroid gland: 15 nTPM
midbrain: 14 nTPM
spinal cord: 14 nTPM
amygdala: 13 nTPM

Single-cell type

adrenal cortex cells: 59 nCPM
myonuclei: 59 nCPM
choroid plexus epithelial cells: 54 nCPM
neutrophil progenitors: 48 nCPM
fibro-adipogenic progenitors: 46 nCPM
adipocytes: 43 nCPM

Immune cell

non-classical monocyte: 13 nTPM
NK-cell: 12 nTPM
MAIT T-cell: 10 nTPM
memory CD8 T-cell: 9.9 nTPM
naive CD4 T-cell: 8.8 nTPM
basophil: 8.5 nTPM

Brain region

white matter: 27 nTPM
basal ganglia: 23 nTPM
medulla oblongata: 23 nTPM
midbrain: 23 nTPM
pons: 23 nTPM
hypothalamus: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.92
gnomAD pLI: 0
gnomAD missense Z: 0.93
DepMap mean gene effect: -0.28
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DIS3L in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DIS3L as an antibody target. Whether an autoantibody or antibody against DIS3L could matter depends on whether native DIS3L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DIS3L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DIS3L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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