PNPase/RNase PH domain superfamily

Definition

Polynucleotide phosphorylase (PNPase) is a polyribonucleotide nucleotidyl transferase [ec:2.7.7.8] that degrades mRNA in prokaryotes. Polynucleotide phosphorylase and the Ribonuclease PH (RNase PH) family possess a common domain represented by this entry. This suggests similar structures and mechanisms of action for these 3'-->5' phosphorolytic enzymes PMID:9241229. In the case of PNPase, the core domain is found duplicated PMID:11080643.

7 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (7 proteins: gene, accession, name)

• EXOSC4
• EXOSC5
• EXOSC6
• EXOSC7
• EXOSC8
• EXOSC9
• PNPT1