SGIP1

Protein identityUniProt · HPA

UniProt accession

Q9BQI5

Gene

SGIP1

Ensembl

ENSG00000118473

Chromosome

1

Canonical length

828 aa

Protein class

Predicted intracellular proteins

Subcellular location

Mitochondria

OverviewNCBI Gene

SGIP1 functions as an endocytic protein that affects signaling by receptors in neuronal systems involved in energy homeostasis via its interaction with endophilins (see SH3GL3; MIM 603362) (Trevaskis et al., 2005 [PubMed 15919751] and Uezu et al., 2007 [PubMed 17626015]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

828 residues, UniProt reviewed canonical sequence.

>Q9BQI5|SGIP1
     1  MMEGLKKRTR KAFGIRKKEK DTDSTGSPDR DGIQPSPHEP PYNSKAECAR EGGKKVSKKS
    61  NGAPNGFYAE IDWERYNSPE LDEEGYSIRP EEPGSTKGKH FYSSSESEEE EESHKKFNIK
   121  IKPLQSKDIL KNAATVDELK ASIGNIALSP SPVRKSPRRS PGAIKRNLSS EEVARPRRST
   181  PTPELISKKP PDDTTALAPL FGPPLESAFD EQKTEVLLDQ PEIWGSGQPI NPSMESPKLT
   241  RPFPTGTPPP LPPKNVPATP PRTGSPLTIG PGNDQSATEV KIEKLPSIND LDSIFGPVLS
   301  PKSVAVNAEE KWVHFSDTSP EHVTPELTPR EKVVSPPATP DNPADSPAPG PLGPPGPTGP
   361  PGPPGPPRNV LSPLNLEEVQ KKVAEQTFIK DDYLETISSP KDFGLGQRAT PPPPPPPTYR
   421  TVVSSPGPGS GPGPGTTSGA SSPARPATPL VPCRSTTPPP PPPRPPSRPK LPPGKPGVGD
   481  VSRPFSPPIH SSSPPPIAPL ARAESTSSIS STNSLSAATT PTVENEQPSL VWFDRGKFYL
   541  TFEGSSRGPS PLTMGAQDTL PVAAAFTETV NAYFKGADPS KCIVKITGEM VLSFPAGITR
   601  HFANNPSPAA LTFRVINFSR LEHVLPNPQL LCCDNTQNDA NTKEFWVNMP NLMTHLKKVS
   661  EQKPQATYYN VDMLKYQVSA QGIQSTPLNL AVNWRCEPSS TDLRIDYKYN TDAMTTAVAL
   721  NNVQFLVPID GGVTKLQAVL PPAVWNAEQQ RILWKIPDIS QKSENGGVGS LLARFQLSEG
   781  PSKPSPLVVQ FTSEGSTLSG CDIELVGAGY RFSLIKKRFA AGKYLADN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SGIP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.57

Highest tissue expression

152 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.2

gnomAD pLI

1

gnomAD missense Z

1.06

DepMap mean gene effect

-0.17

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• clathrin-dependent endocytosis
• energy homeostasis
• positive regulation of feeding behavior
• positive regulation of receptor-mediated endocytosis
• response to dietary excess
• synaptic vesicle endocytosis

Molecular functions

• microtubule binding
• phospholipid binding
• SH3 domain binding

Cellular components

• AP-2 adaptor complex
• clathrin-coated pit
• clathrin-coated vesicle
• cytoplasm
• cytosol
• plasma membrane
• presynapse

Protein domainsUniProt · Pfam · InterPro

• Muniscin, C-terminal
• Mu homology domain
• AP-2 complex subunit mu, C-terminal superfamily
• Muniscin C-terminal mu homology domain
• SGIP1, mu-homology domain

KeywordsUniProt

• Coated pit
• Endocytosis
• Membrane
• Phosphoprotein

InteractionsUniProt · HPA

Protein binding partners of SGIP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• AMPH
• AP2A1
• CANX
• EPS15
• ITSN1
• SH3GL3
• EPS15L1