Seroatlas · Human Serome Atlas

AP2A2

AP-2 complex subunit alpha-2

Also known as: ADTAB, AP2A2_HUMAN, CLAPA2, DKFZP564D1864, HIP9, HYPJ, KIAA0899

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O94973
Gene
AP2A2
Ensembl
ENSG00000183020
Chromosome
11
Canonical length
939 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Transporters
Subcellular location
Nucleoplasm,Vesicles

OverviewNCBI Gene

The protein encoded by this gene is a subunit of the AP-2 adaptor protein complex, which is involved in linking lipid and protein membrane components with the clathrin lattice. This interaction supports the formation of clathrin-coated vesicles, and the encoded subunit aids in the process by binding polyphosphoinositide-containing lipids in the cell membrane. [provided by RefSeq, Nov 2016]

Canonical amino-acid sequenceUniProt

939 residues, UniProt reviewed canonical sequence.

>O94973|AP2A2
     1  MPAVSKGDGM RGLAVFISDI RNCKSKEAEI KRINKELANI RSKFKGDKAL DGYSKKKYVC
    61  KLLFIFLLGH DIDFGHMEAV NLLSSNRYTE KQIGYLFISV LVNSNSELIR LINNAIKNDL
   121  ASRNPTFMGL ALHCIASVGS REMAEAFAGE IPKVLVAGDT MDSVKQSAAL CLLRLYRTSP
   181  DLVPMGDWTS RVVHLLNDQH LGVVTAATSL ITTLAQKNPE EFKTSVSLAV SRLSRIVTSA
   241  STDLQDYTYY FVPAPWLSVK LLRLLQCYPP PDPAVRGRLT ECLETILNKA QEPPKSKKVQ
   301  HSNAKNAVLF EAISLIIHHD SEPNLLVRAC NQLGQFLQHR ETNLRYLALE SMCTLASSEF
   361  SHEAVKTHIE TVINALKTER DVSVRQRAVD LLYAMCDRSN APQIVAEMLS YLETADYSIR
   421  EEIVLKVAIL AEKYAVDYTW YVDTILNLIR IAGDYVSEEV WYRVIQIVIN RDDVQGYAAK
   481  TVFEALQAPA CHENLVKVGG YILGEFGNLI AGDPRSSPLI QFHLLHSKFH LCSVPTRALL
   541  LSTYIKFVNL FPEVKPTIQD VLRSDSQLRN ADVELQQRAV EYLRLSTVAS TDILATVLEE
   601  MPPFPERESS ILAKLKKKKG PSTVTDLEDT KRDRSVDVNG GPEPAPASTS AVSTPSPSAD
   661  LLGLGAAPPA PAGPPPSSGG SGLLVDVFSD SASVVAPLAP GSEDNFARFV CKNNGVLFEN
   721  QLLQIGLKSE FRQNLGRMFI FYGNKTSTQF LNFTPTLICS DDLQPNLNLQ TKPVDPTVEG
   781  GAQVQQVVNI ECVSDFTEAP VLNIQFRYGG TFQNVSVQLP ITLNKFFQPT EMASQDFFQR
   841  WKQLSNPQQE VQNIFKAKHP MDTEVTKAKI IGFGSALLEE VDPNPANFVG AGIIHTKTTQ
   901  IGCLLRLEPN LQAQMYRLTL RTSKEAVSQR LCELLSAQF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AP2A2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
50 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 50 nTPM
  • spleen: 31 nTPM
  • cerebral cortex: 31 nTPM
  • kidney: 22 nTPM
  • basal ganglia: 18 nTPM
  • hypothalamus: 18 nTPM

Single-cell type

  • proximal tubule cells: 209 nCPM
  • renal connecting tubule cells: 199 nCPM
  • distal convoluted tubule cells: 198 nCPM
  • loop of henle epithelial cells: 127 nCPM
  • renal collecting duct intercalated cells: 118 nCPM
  • renal collecting duct principal cells: 110 nCPM

Immune cell

  • classical monocyte: 1.8 nTPM
  • eosinophil: 1.4 nTPM
  • T-reg: 1.3 nTPM
  • gdT-cell: 1.2 nTPM
  • neutrophil: 1.2 nTPM
  • plasmacytoid DC: 1.1 nTPM

Brain region

  • cerebral cortex: 27 nTPM
  • cerebellum: 25 nTPM
  • medulla oblongata: 22 nTPM
  • pons: 21 nTPM
  • hippocampal formation: 20 nTPM
  • amygdala: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.11
gnomAD pLI
1
gnomAD missense Z
3.13
DepMap mean gene effect
0.09
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of AP2A2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AP2A2 as an antibody target. Whether an autoantibody or antibody against AP2A2 could matter depends on whether native AP2A2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AP2A2 is annotated at the cell surface, where native AP2A2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label AP2A2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/AP2A2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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