Seroatlas · Human Serome Atlas

AGFG1

Arf-GAP domain and FG repeat-containing protein 1

Also known as: AGFG1_HUMAN, HRB, RAB, RIP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P52594
Gene
AGFG1
Ensembl
ENSG00000173744
Chromosome
2
Canonical length
562 aa
Protein class
Predicted intracellular proteins
Subcellular location
Vesicles

OverviewNCBI Gene

The protein encoded by this gene is related to nucleoporins, a class of proteins that mediate nucleocytoplasmic transport. The encoded protein binds the activation domain of the human immunodeficiency virus Rev protein when Rev is assembled onto its RNA target, and is required for the nuclear export of Rev-directed RNAs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

Canonical amino-acid sequenceUniProt

562 residues, UniProt reviewed canonical sequence.

>P52594|AGFG1
     1  MAASAKRKQE EKHLKMLRDM TGLPHNRKCF DCDQRGPTYV NMTVGSFVCT SCSGSLRGLN
    61  PPHRVKSISM TTFTQQEIEF LQKHGNEVCK QIWLGLFDDR SSAIPDFRDP QKVKEFLQEK
   121  YEKKRWYVPP EQAKVVASVH ASISGSSASS TSSTPEVKPL KSLLGDSAPT LHLNKGTPSQ
   181  SPVVGRSQGQ QQEKKQFDLL SDLGSDIFAA PAPQSTATAN FANFAHFNSH AAQNSANADF
   241  ANFDAFGQSS GSSNFGGFPT ASHSPFQPQT TGGSAASVNA NFAHFDNFPK SSSADFGTFN
   301  TSQSHQTASA VSKVSTNKAG LQTADKYAAL ANLDNIFSAG QGGDQGSGFG TTGKAPVGSV
   361  VSVPSQSSAS SDKYAALAEL DSVFSSAATS SNAYTSTSNA SSNVFGTVPV VASAQTQPAS
   421  SSVPAPFGAT PSTNPFVAAA GPSVASSTNP FQTNARGATA ATFGTASMSM PTGFGTPAPY
   481  SLPTSFSGSF QQPAFPAQAA FPQQTAFSQQ PNGAGFAAFG QTKPVVTPFG QVAAAGVSSN
   541  PFMTGAPTGQ FPTGSSSTNP FL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AGFG1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.63
Highest tissue expression
147 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 147 nTPM
  • testis: 87 nTPM
  • placenta: 71 nTPM
  • adipose tissue: 65 nTPM
  • urinary bladder: 61 nTPM
  • spinal cord: 54 nTPM

Single-cell type

  • neutrophils: 1,538 nCPM
  • monocytes: 644 nCPM
  • neutrophil progenitors: 597 nCPM
  • late spermatids: 586 nCPM
  • monocyte progenitors: 307 nCPM
  • kupffer cells: 290 nCPM

Immune cell

  • neutrophil: 5.6 nTPM
  • classical monocyte: 5.4 nTPM
  • intermediate monocyte: 4.3 nTPM
  • non-classical monocyte: 4.2 nTPM
  • basophil: 4.1 nTPM
  • naive B-cell: 3.5 nTPM

Brain region

  • white matter: 115 nTPM
  • thalamus: 94 nTPM
  • medulla oblongata: 91 nTPM
  • spinal cord: 89 nTPM
  • cerebral cortex: 88 nTPM
  • basal ganglia: 83 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.28
gnomAD pLI
0.99
gnomAD missense Z
1.66
DepMap mean gene effect
0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of AGFG1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AGFG1 as an antibody target. Whether an autoantibody or antibody against AGFG1 could matter depends on whether native AGFG1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AGFG1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AGFG1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/AGFG1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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