Seroatlas · Human Serome Atlas

ATXN7L2

Ataxin-7-like protein 2

Also known as: AT7L2_HUMAN, FLJ00381, MGC46534

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5T6C5
Gene: ATXN7L2
Ensembl: ENSG00000162650
Chromosome: 1
Canonical length: 722 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli rim,Vesicles,Cytosol

OverviewNCBI Gene

No narrative summary is available for ATXN7L2 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

722 residues, UniProt reviewed canonical sequence.

>Q5T6C5|ATXN7L2
     1  MAVRERAAAA MAALERRVPS LDDFAGQSWS SWVERADLPA ADGAELEESS KNTKKLDAMT
    61  LIKEDMSIFG HCPAHDDFYL VVCNHCSQVV KPQAFQKHCE RRHGPLSKLY GRAPPPPPAP
   121  ASSQKCHVVN GQGPACRAPG STKTSSREKG QGSRSRGHQP PEKTQKDNLC QPGGLTKDSP
   181  GKPPMAPPSK EPPGRENIEI IPSEGSSHWA EGSPPEKEPS GTRLPPKTHR KMARKECDLN
   241  RQCGVINPET KKICTRLLTC KIHSVHQRRE VQGRAKDFDV LVAELKANSR KGESPKEKSP
   301  GRKEQVLERP SQELPSSVQV VAAVAAPSST FSVRAKQTYP YCALPRSRAS SESELDDEGP
   361  CGGDGDPGLF PFPMPRGGTQ ASSEESEEEG TSDDLHPPPD CHYATRPPRP QAFCTFGSRL
   421  VSPGCYVFSR RLDRFCSALS SMLERHLSTH MWKKIPPAAE PPAHLVNSPL SAPLSPSSTG
   481  TCPRLPGPTL RPACPASMPP TKDNLVPSYP AGSPSVAAAC SQAECMGGSQ AITSPLPANT
   541  PSPSFSKLPP SKASKSSKGK DGVEVEAPSR KRKLSPGPTT LKRTCILEPT GKGKPSGCRG
   601  LSAKTKTALS MGLNGTMGPR VKRAGPLDCR GSPHQLPTPV KASQLENRGA AGHPAKALPT
   661  NCLSEEEVAK KRKNLATYCR PVKAKHCQAG APADVACSVR RKKPGPALAF EEKCSTLKSK
   721  AH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ATXN7L2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.67
Highest tissue expression: 3.2 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 3.2 nTPM
testis: 2.6 nTPM
ovary: 1.7 nTPM
thymus: 1.7 nTPM
tongue: 1.4 nTPM
skeletal muscle: 1.3 nTPM

Single-cell type

myonuclei: 22 nCPM
sertoli cells: 19 nCPM
adrenal medulla cells: 11 nCPM
astrocytes: 8.5 nCPM
brain excitatory neurons: 7.8 nCPM
late primary spermatocytes: 7.2 nCPM

Immune cell

memory CD8 T-cell: 3.6 nTPM
gdT-cell: 3.5 nTPM
MAIT T-cell: 3.2 nTPM
T-reg: 3 nTPM
memory CD4 T-cell: 2.8 nTPM
naive CD8 T-cell: 2.4 nTPM

Brain region

hippocampal formation: 4.2 nTPM
cerebral cortex: 3.8 nTPM
white matter: 2.6 nTPM
basal ganglia: 2.4 nTPM
midbrain: 2.2 nTPM
amygdala: 1.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.38
gnomAD pLI: 0.87
gnomAD missense Z: 1.16
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Phosphoprotein

InteractionsUniProt · HPA

Protein binding partners of ATXN7L2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ATXN7L2 as an antibody target. Whether an autoantibody or antibody against ATXN7L2 could matter depends on whether native ATXN7L2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ATXN7L2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ATXN7L2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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