Seroatlas · Human Serome Atlas

USP51

Ubiquitin carboxyl-terminal hydrolase 51

Also known as: UBP51_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q70EK9
Gene: USP51
Ensembl: ENSG00000247746
Chromosome: X
Canonical length: 711 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoli fibrillar center,Cytosol

OverviewNCBI Gene

Enables chromatin binding activity; deubiquitinase activity; and histone binding activity. Involved in DNA repair-dependent chromatin remodeling; regulation of cell cycle process; and regulation of double-strand break repair. Predicted to be located in chromosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

711 residues, UniProt reviewed canonical sequence.

>Q70EK9|USP51
     1  MAQVRETSLP SGSGVRWISG GGGGASPEEA VEKAGKMEEA AAGATKASSR REAEEMKLEP
    61  LQEREPAPEE NLTWSSSGGD EKVLPSIPLR CHSSSSPVCP RRKPRPRPQP RARSRSQPGL
   121  SAPPPPPARP PPPPPPPPPP APRPRAWRGS RRRSRPGSRP QTRRSCSGDL DGSGDPGGLG
   181  DWLLEVEFGQ GPTGCSHVES FKVGKNWQKN LRLIYQRFVW SGTPETRKRK AKSCICHVCS
   241  THMNRLHSCL SCVFFGCFTE KHIHKHAETK QHHLAVDLYH GVIYCFMCKD YVYDKDIEQI
   301  AKETKEKILR LLTSTSTDVS HQQFMTSGFE DKQSTCETKE QEPKLVKPKK KRRKKSVYTV
   361  GLRGLINLGN TCFMNCIVQA LTHIPLLKDF FLSDKHKCIM TSPSLCLVCE MSSLFHAMYS
   421  GSRTPHIPYK LLHLIWIHAE HLAGYRQQDA HEFLIAILDV LHRHSKDDSG GQEANNPNCC
   481  NCIIDQIFTG GLQSDVTCQA CHSVSTTIDP CWDISLDLPG SCATFDSQNP ERADSTVSRD
   541  DHIPGIPSLT DCLQWFTRPE HLGSSAKIKC NSCQSYQEST KQLTMKKLPI VACFHLKRFE
   601  HVGKQRRKIN TFISFPLELD MTPFLASTKE SRMKEGQPPT DCVPNENKYS LFAVINHHGT
   661  LESGHYTSFI RQQKDQWFSC DDAIITKATI EDLLYSEGYL LFYHKQGLEK D

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against USP51 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 47 nTPM

Expression across tissuesHPA

Tissue

epididymis: 47 nTPM
parathyroid gland: 5.3 nTPM
fallopian tube: 5.1 nTPM
thyroid gland: 4.9 nTPM
ovary: 4.7 nTPM
kidney: 3.4 nTPM

Single-cell type

epididymal principal cells: 260 nCPM
respiratory ciliated cells: 43 nCPM
fallopian tube ciliated cells: 41 nCPM
müller glia: 36 nCPM
epididymal clear cells: 35 nCPM
epididymal efferent duct absorptive cells: 27 nCPM

Immune cell

eosinophil: 0.6 nTPM
naive CD4 T-cell: 0.5 nTPM
memory B-cell: 0.1 nTPM
memory CD4 T-cell: 0.1 nTPM
naive B-cell: 0.1 nTPM
NK-cell: 0.1 nTPM

Brain region

choroid plexus: 8.7 nTPM
hypothalamus: 8.7 nTPM
midbrain: 6.2 nTPM
cerebellum: 5.7 nTPM
basal ganglia: 5.5 nTPM
pons: 5 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about USP51.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 83 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Short stature

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.65
gnomAD pLI: 0.13
gnomAD missense Z: 1.13
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of USP51 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads USP51 as an antibody target. Whether an autoantibody or antibody against USP51 could matter depends on whether native USP51 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

USP51 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label USP51 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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