Seroatlas · Human Serome Atlas

HOOK3

Protein Hook homolog 3

Also known as: HK3, HOOK3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q86VS8
Gene
HOOK3
Ensembl
ENSG00000168172
Chromosome
8
Canonical length
718 aa
Protein class
Cancer-related genes, Predicted intracellular proteins
Subcellular location
Golgi apparatus,Centriolar satellite,Cytosol

OverviewNCBI Gene

Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment.[supplied by OMIM, Apr 2004]

Canonical amino-acid sequenceUniProt

718 residues, UniProt reviewed canonical sequence.

>Q86VS8|HOOK3
     1  MFSVESLERA ELCESLLTWI QTFNVDAPCQ TVEDLTNGVV MAQVLQKIDP AYFDENWLNR
    61  IKTEVGDNWR LKISNLKKIL KGILDYNHEI LGQQINDFTL PDVNLIGEHS DAAELGRMLQ
   121  LILGCAVNCE QKQEYIQAIM MMEESVQHVV MTAIQELMSK ESPVSAGNDA YVDLDRQLKK
   181  TTEELNEALS AKEEIAQRCH ELDMQVAALQ EEKSSLLAEN QVLMERLNQS DSIEDPNSPA
   241  GRRHLQLQTQ LEQLQEETFR LEAAKDDYRI RCEELEKEIS ELRQQNDELT TLADEAQSLK
   301  DEIDVLRHSS DKVSKLEGQV ESYKKKLEDL GDLRRQVKLL EEKNTMYMQN TVSLEEELRK
   361  ANAARSQLET YKRQVVELQN RLSEESKKAD KLDFEYKRLK EKVDSLQKEK DRLRTERDSL
   421  KETIEELRCV QAQEGQLTTQ GLMPLGSQES SDSLAAEIVT PEIREKLIRL QHENKMLKLN
   481  QEGSDNEKIA LLQSLLDDAN LRKNELETEN RLVNQRLLEV QSQVEELQKS LQDQGSKAED
   541  SVLLKKKLEE HLEKLHEANN ELQKKRAIIE DLEPRFNNSS LKIEELQEAL RKKEEEMKQM
   601  EERYKKYLEK AKSVIRTLDP KQNQGAAPEI QALKNQLQER DRLFHSLEKE YEKTKSQREM
   661  EEKYIVSAWY NMGMTLHKKA AEDRLASTGS GQSFLARQRQ ATSSRRSYPG HVQPATAR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HOOK3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.45
Highest tissue expression
20 nTPM

Expression across tissuesHPA

Tissue

  • thyroid gland: 20 nTPM
  • esophagus: 10 nTPM
  • skeletal muscle: 9.9 nTPM
  • cerebral cortex: 9.5 nTPM
  • prostate: 9.5 nTPM
  • gallbladder: 9.4 nTPM

Single-cell type

  • urothelial cells: 554 nCPM
  • endometrial luminal cells: 312 nCPM
  • neutrophils: 271 nCPM
  • mast cells: 246 nCPM
  • oligodendrocytes: 237 nCPM
  • syncytiotrophoblasts: 237 nCPM

Immune cell

  • basophil: 6 nTPM
  • eosinophil: 4.2 nTPM
  • myeloid DC: 4.1 nTPM
  • classical monocyte: 4 nTPM
  • intermediate monocyte: 3.2 nTPM
  • neutrophil: 3 nTPM

Brain region

  • cerebellum: 54 nTPM
  • white matter: 52 nTPM
  • cerebral cortex: 50 nTPM
  • hypothalamus: 48 nTPM
  • basal ganglia: 46 nTPM
  • medulla oblongata: 45 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about HOOK3.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 87 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.16
gnomAD pLI
1
gnomAD missense Z
2.36
DepMap mean gene effect
0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HOOK3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HOOK3 as an antibody target. Whether an autoantibody or antibody against HOOK3 could matter depends on whether native HOOK3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HOOK3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HOOK3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/HOOK3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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