Dynein axonemal intermediate chain 1/2/3/4
IPR050687
Definition
The dynein intermediate chain family is involved in the structure and function of dynein complexes, which are motor proteins that drive the movement of vesicles, organelles, and other cargos along microtubules. Members of the family play roles in linking dynein to these cargos and to adapter proteins, regulating dynein function. They are essential for intracellular retrograde motility, ciliary motility, and are involved in various cellular processes including ciliogenesis, cell migration, and mitosis. Some members act as negative regulators of signaling pathways and are involved in the assembly of the axonemal dynein complex, critical for respiratory cilia function and potentially in the regulation of cilia function more broadly.
7 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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