Seroatlas · Human Serome Atlas

DCTN4

Dynactin subunit 4

Also known as: DCTN4_HUMAN, Dyn4, p62

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UJW0
Gene: DCTN4
Ensembl: ENSG00000132912
Chromosome: 5
Canonical length: 460 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Centrosome,Calyx

OverviewNCBI Gene

Located in centrosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

460 residues, UniProt reviewed canonical sequence.

>Q9UJW0|DCTN4
     1  MASLLQSDRV LYLVQGEKKV RAPLSQLYFC RYCSELRSLE CVSHEVDSHY CPSCLENMPS
    61  AEAKLKKNRC ANCFDCPGCM HTLSTRATSI STQLPDDPAK TTMKKAYYLA CGFCRWTSRD
   121  VGMADKSVAS GGWQEPENPH TQRMNKLIEY YQQLAQKEKV ERDRKKLARR RNYMPLAFSD
   181  KYGLGTRLQR PRAGASISTL AGLSLKEGED QKEIKIEPAQ AVDEVEPLPE DYYTRPVNLT
   241  EVTTLQQRLL QPDFQPVCAS QLYPRHKHLL IKRSLRCRKC EHNLSKPEFN PTSIKFKIQL
   301  VAVNYIPEVR IMSIPNLRYM KESQVLLTLT NPVENLTHVT LFECEEGDPD DINSTAKVVV
   361  PPKELVLAGK DAAAEYDELA EPQDFQDDPD IIAFRKANKV GIFIKVTPQR EEGEVTVCFK
   421  MKHDFKNLAA PIRPIEESDQ GTEVIWLTQH VELSLGPLLP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DCTN4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 55 nTPM

Expression across tissuesHPA

Tissue

retina: 55 nTPM
bone marrow: 54 nTPM
skeletal muscle: 45 nTPM
cerebral cortex: 38 nTPM
pancreas: 36 nTPM
tongue: 34 nTPM

Single-cell type

neutrophils: 315 nCPM
neutrophil progenitors: 185 nCPM
monocytes: 151 nCPM
pdcs: 142 nCPM
monocyte progenitors: 135 nCPM
pituicytes/fscs: 132 nCPM

Immune cell

neutrophil: 16 nTPM
classical monocyte: 11 nTPM
eosinophil: 11 nTPM
myeloid DC: 11 nTPM
intermediate monocyte: 7.8 nTPM
non-classical monocyte: 6.9 nTPM

Brain region

white matter: 120 nTPM
pons: 110 nTPM
cerebral cortex: 106 nTPM
medulla oblongata: 105 nTPM
cerebellum: 102 nTPM
hypothalamus: 102 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.39
gnomAD pLI: 0.73
gnomAD missense Z: 1.44
DepMap mean gene effect: -0.88
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

Dynactin subunit 4
Dynactin p62 family

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DCTN4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DCTN4 as an antibody target. Whether an autoantibody or antibody against DCTN4 could matter depends on whether native DCTN4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DCTN4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DCTN4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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