Amidohydrolase-related
IPR006680
Definition
Proteins containing this domain are enzymes from a large metal-dependent hydrolase superfamily [interpro:IPR032466] PMID:9144792. The family includes adenine deaminase ([ec:3.5.4.2]) that hydrolyses adenine to form hypoxanthine and ammonia. This reaction is important for adenine utilisation as a purine and also as a nitrogen source PMID:8550522. The entry also includes dihydroorotase and N-acetylglucosamine-6-phosphate deacetylases ([ec:3.5.1.25]). The domain is also found in the urease alpha subunit, where it is the catalytic domain PMID:7754395.
11 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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