CRMP1

Protein identityUniProt · HPA

UniProt accession

Q14194

Gene

CRMP1

Ensembl

ENSG00000072832

Chromosome

4

Canonical length

572 aa

Protein class

Predicted intracellular proteins

Subcellular location

Centrosome,Cytosol

Quaternary structure

Homotetramer

OverviewNCBI Gene

This gene encodes a member of a family of cytosolic phosphoproteins expressed exclusively in the nervous system. The encoded protein is thought to be a part of the semaphorin signal transduction pathway implicated in semaphorin-induced growth cone collapse during neural development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

572 residues, UniProt reviewed canonical sequence.

>Q14194|CRMP1
     1  MSYQGKKSIP HITSDRLLIK GGRIINDDQS LYADVYLEDG LIKQIGENLI VPGGVKTIEA
    61  NGRMVIPGGI DVNTYLQKPS QGMTAADDFF QGTRAALVGG TTMIIDHVVP EPGSSLLTSF
   121  EKWHEAADTK SCCDYSLHVD ITSWYDGVRE ELEVLVQDKG VNSFQVYMAY KDVYQMSDSQ
   181  LYEAFTFLKG LGAVILVHAE NGDLIAQEQK RILEMGITGP EGHALSRPEE LEAEAVFRAI
   241  TIAGRINCPV YITKVMSKSA ADIIALARKK GPLVFGEPIA ASLGTDGTHY WSKNWAKAAA
   301  FVTSPPLSPD PTTPDYLTSL LACGDLQVTG SGHCPYSTAQ KAVGKDNFTL IPEGVNGIEE
   361  RMTVVWDKAV ATGKMDENQF VAVTSTNAAK IFNLYPRKGR IAVGSDADVV IWDPDKLKTI
   421  TAKSHKSAVE YNIFEGMECH GSPLVVISQG KIVFEDGNIN VNKGMGRFIP RKAFPEHLYQ
   481  RVKIRNKVFG LQGVSRGMYD GPVYEVPATP KYATPAPSAK SSPSKHQPPP IRNLHQSNFS
   541  LSGAQIDDNN PRRTGHRIVA PPGGRSNITS LG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CRMP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.28

Highest tissue expression

83 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CRMP1.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 131 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• See cases

ReferencesPubMed · IEDB

Publications for CRMP1 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. IEDB — curated epitope assays from the Immune Epitope Database (Vita et al., Nucleic Acids Research 2019). Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.28

gnomAD pLI

0.99

gnomAD missense Z

2.41

DepMap mean gene effect

-0.04

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• negative regulation of neuron projection development
• nervous system development
• nucleobase-containing compound metabolic process
• regulation of postsynapse assembly
• semaphorin-plexin signaling pathway

Molecular functions

• filamin binding
• hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
• identical protein binding
• phosphoprotein binding

Cellular components

• actin cytoskeleton
• centrosome
• cytosol
• dendrite
• growth cone
• midbody
• perikaryon
• postsynapse
• presynapse
• spindle

Protein domainsUniProt · Pfam · InterPro

• Amidohydrolase-related
• Metal-dependent hydrolase, composite domain superfamily
• Hydantoinase/dihydropyrimidinase
• Metal-dependent hydrolase
• Metallo-dependent Hydrolases Superfamily
• Amidohydrolase family

KeywordsUniProt

• Cell projection
• Cytoplasm
• Cytoskeleton
• Nitration
• Phosphoprotein

InteractionsUniProt · HPA

Protein binding partners of CRMP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• FLNA
• PLXNA1
• DPYSL2
• HTT
• TK1
• VIM