Seroatlas · Human Serome Atlas

MICALL1

MICAL-like protein 1

Also known as: KIAA1668, MICAL-L1, MILK1_HUMAN, MIRAB13

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N3F8
Gene
MICALL1
Ensembl
ENSG00000100139
Chromosome
22
Canonical length
863 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Cell Junctions,Centriolar satellite,Cytosol
Quaternary structure
Homooligomer

OverviewNCBI Gene

Enables several functions, including identical protein binding activity; phosphatidic acid binding activity; and small GTPase binding activity. Involved in several processes, including plasma membrane tubulation; protein localization to organelle; and slow endocytic recycling. Located in centriole; cilium; and endosome. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

863 residues, UniProt reviewed canonical sequence.

>Q8N3F8|MICALL1
     1  MAGPRGALLA WCRRQCEGYR GVEIRDLSSS FRDGLAFCAI LHRHRPDLLD FDSLSKDNVF
    61  ENNRLAFEVA EKELGIPALL DPNDMVSMSV PDCLSIMTYV SQYYNHFCSP GQAGVSPPRK
   121  GLAPCSPPSV APTPVEPEDV AQGEELSSGS LSEQGTGQTP SSTCAACQQH VHLVQRYLAD
   181  GRLYHRHCFR CRRCSSTLLP GAYENGPEEG TFVCAEHCAR LGPGTRSGTR PGPFSQPKQQ
   241  HQQQLAEDAK DVPGGGPSSS APAGAEADGP KASPEARPQI PTKPRVPGKL QELASPPAGR
   301  PTPAPRKASE STTPAPPTPR PRSSLQQENL VEQAGSSSLV NGRLHELPVP KPRGTPKPSE
   361  GTPAPRKDPP WITLVQAEPK KKPAPLPPSS SPGPPSQDSR QVENGGTEEV AQPSPTASLE
   421  SKPYNPFEEE EEDKEEEAPA APSLATSPAL GHPESTPKSL HPWYGITPTS SPKTKKRPAP
   481  RAPSASPLAL HASRLSHSEP PSATPSPALS VESLSSESAS QTAGAELLEP PAVPKSSSEP
   541  AVHAPGTPGN PVSLSTNSSL ASSGELVEPR VEQMPQASPG LAPRTRGSSG PQPAKPCSGA
   601  TPTPLLLVGD RSPVPSPGSS SPQLQVKSSC KENPFNRKPS PAASPATKKA TKGSKPVRPP
   661  APGHGFPLIK RKVQADQYIP EEDIHGEMDT IERRLDALEH RGVLLEEKLR GGLNEGREDD
   721  MLVDWFKLIH EKHLLVRRES ELIYVFKQQN LEQRQADVEY ELRCLLNKPE KDWTEEDRAR
   781  EKVLMQELVT LIEQRNAIIN CLDEDRQREE EEDKMLEAMI KKKEFQREAE PEGKKKGKFK
   841  TMKMLKLLGN KRDAKSKSPR DKS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MICALL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.56
Highest tissue expression
39 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 39 nTPM
  • stomach: 35 nTPM
  • colon: 32 nTPM
  • skin: 30 nTPM
  • endometrium: 25 nTPM
  • urinary bladder: 23 nTPM

Single-cell type

  • parietal cells: 94 nCPM
  • esophageal apical cells: 84 nCPM
  • esophageal suprabasal cells: 80 nCPM
  • syncytiotrophoblasts: 70 nCPM
  • cytotrophoblasts: 67 nCPM
  • migrating cytotrophoblasts: 63 nCPM

Immune cell

  • plasmacytoid DC: 0.6 nTPM
  • memory CD8 T-cell: 0.5 nTPM
  • naive B-cell: 0.5 nTPM
  • neutrophil: 0.5 nTPM
  • NK-cell: 0.5 nTPM
  • gdT-cell: 0.4 nTPM

Brain region

  • white matter: 49 nTPM
  • medulla oblongata: 47 nTPM
  • pons: 42 nTPM
  • midbrain: 40 nTPM
  • cerebellum: 38 nTPM
  • thalamus: 37 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.75
gnomAD pLI
0
gnomAD missense Z
0.98
DepMap mean gene effect
-0.12
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MICALL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MICALL1 as an antibody target. Whether an autoantibody or antibody against MICALL1 could matter depends on whether native MICALL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MICALL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MICALL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MICALL1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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