Seroatlas · Human Serome Atlas

ARID1B

AT-rich interactive domain-containing protein 1B

Also known as: 6A3-5, ARI1B_HUMAN, BAF250b, DAN15, ELD/OSA1, KIAA1235, p250R, SMARCF2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NFD5
Gene
ARID1B
Ensembl
ENSG00000049618
Chromosome
6
Canonical length
2319 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This locus encodes an AT-rich DNA interacting domain-containing protein. The encoded protein is a component of the SWI/SNF chromatin remodeling complex and may play a role in cell-cycle activation. The protein encoded by this locus is similar to AT-rich interactive domain-containing protein 1A. These two proteins function as alternative, mutually exclusive ARID-subunits of the SWI/SNF complex. The associated complexes play opposing roles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]

Canonical amino-acid sequenceUniProt

2319 residues, UniProt reviewed canonical sequence.

>Q8NFD5|ARID1B
     1  MAARAAAAAA AAAARARARA GSGERRAPPG PRPAPGARDL EAGARGAAAA AAAPGPMLGG
    61  GGDGGGGLNS VHHHPLLPRH ELNMAHNAGA AAAAGTHSAK SGGSEAALKE GGSAAALSSS
   121  SSSSAAAAAA SSSSSSGPGS AMETGLLPNH KLKTVGEAPA APPHQQHHHH HHAHHHHHHA
   181  HHLHHHHALQ QQLNQFQQQQ QQQQQQQQQQ QQQQHPISNN NSLGGAGGGA PQPGPDMEQP
   241  QHGGAKDSAA GGQADPPGPP LLSKPGDEDD APPKMGEPAG GRYEHPGLGA LGTQQPPVAV
   301  PGGGGGPAAV PEFNNYYGSA APASGGPGGR AGPCFDQHGG QQSPGMGMMH SASAAAAGAP
   361  GSMDPLQNSH EGYPNSQCNH YPGYSRPGAG GGGGGGGGGG GGSGGGGGGG GAGAGGAGAG
   421  AVAAAAAAAA AAAGGGGGGG YGGSSAGYGV LSSPRQQGGG MMMGPGGGGA ASLSKAAAGS
   481  AAGGFQRFAG QNQHPSGATP TLNQLLTSPS PMMRSYGGSY PEYSSPSAPP PPPSQPQSQA
   541  AAAGAAAGGQ QAAAGMGLGK DMGAQYAAAS PAWAAAQQRS HPAMSPGTPG PTMGRSQGSP
   601  MDPMVMKRPQ LYGMGSNPHS QPQQSSPYPG GSYGPPGPQR YPIGIQGRTP GAMAGMQYPQ
   661  QQMPPQYGQQ GVSGYCQQGQ QPYYSQQPQP PHLPPQAQYL PSQSQQRYQP QQDMSQEGYG
   721  TRSQPPLAPG KPNHEDLNLI QQERPSSLPD LSGSIDDLPT GTEATLSSAV SASGSTSSQG
   781  DQSNPAQSPF SPHASPHLSS IPGGPSPSPV GSPVGSNQSR SGPISPASIP GSQMPPQPPG
   841  SQSESSSHPA LSQSPMPQER GFMAGTQRNP QMAQYGPQQT GPSMSPHPSP GGQMHAGISS
   901  FQQSNSSGTY GPQMSQYGPQ GNYSRPPAYS GVPSASYSGP GPGMGISANN QMHGQGPSQP
   961  CGAVPLGRMP SAGMQNRPFP GNMSSMTPSS PGMSQQGGPG MGPPMPTVNR KAQEAAAAVM
  1021  QAAANSAQSR QGSFPGMNQS GLMASSSPYS QPMNNSSSLM NTQAPPYSMA PAMVNSSAAS
  1081  VGLADMMSPG ESKLPLPLKA DGKEEGTPQP ESKSKKSSSS TTTGEKITKV YELGNEPERK
  1141  LWVDRYLTFM EERGSPVSSL PAVGKKPLDL FRLYVCVKEI GGLAQVNKNK KWRELATNLN
  1201  VGTSSSAASS LKKQYIQYLF AFECKIERGE EPPPEVFSTG DTKKQPKLQP PSPANSGSLQ
  1261  GPQTPQSTGS NSMAEVPGDL KPPTPASTPH GQMTPMQGGR SSTISVHDPF SDVSDSSFPK
  1321  RNSMTPNAPY QQGMSMPDVM GRMPYEPNKD PFGGMRKVPG SSEPFMTQGQ MPNSSMQDMY
  1381  NQSPSGAMSN LGMGQRQQFP YGASYDRRHE PYGQQYPGQG PPSGQPPYGG HQPGLYPQQP
  1441  NYKRHMDGMY GPPAKRHEGD MYNMQYSSQQ QEMYNQYGGS YSGPDRRPIQ GQYPYPYSRE
  1501  RMQGPGQIQT HGIPPQMMGG PLQSSSSEGP QQNMWAARND MPYPYQNRQG PGGPTQAPPY
  1561  PGMNRTDDMM VPDQRINHES QWPSHVSQRQ PYMSSSASMQ PITRPPQPSY QTPPSLPNHI
  1621  SRAPSPASFQ RSLENRMSPS KSPFLPSMKM QKVMPTVPTS QVTGPPPQPP PIRREITFPP
  1681  GSVEASQPVL KQRRKITSKD IVTPEAWRVM MSLKSGLLAE STWALDTINI LLYDDSTVAT
  1741  FNLSQLSGFL ELLVEYFRKC LIDIFGILME YEVGDPSQKA LDHNAARKDD SQSLADDSGK
  1801  EEEDAECIDD DEEDEEDEEE DSEKTESDEK SSIALTAPDA AADPKEKPKQ ASKFDKLPIK
  1861  IVKKNNLFVV DRSDKLGRVQ EFNSGLLHWQ LGGGDTTEHI QTHFESKMEI PPRRRPPPPL
  1921  SSAGRKKEQE GKGDSEEQQE KSIIATIDDV LSARPGALPE DANPGPQTES SKFPFGIQQA
  1981  KSHRNIKLLE DEPRSRDETP LCTIAHWQDS LAKRCICVSN IVRSLSFVPG NDAEMSKHPG
  2041  LVLILGKLIL LHHEHPERKR APQTYEKEED EDKGVACSKD EWWWDCLEVL RDNTLVTLAN
  2101  ISGQLDLSAY TESICLPILD GLLHWMVCPS AEAQDPFPTV GPNSVLSPQR LVLETLCKLS
  2161  IQDNNVDLIL ATPPFSRQEK FYATLVRYVG DRKNPVCREM SMALLSNLAQ GDALAARAIA
  2221  VQKGSIGNLI SFLEDGVTMA QYQQSQHNLM HMQPPPLEPP SVDMMCRAAK ALLAMARVDE
  2281  NRSEFLLHEG RLLDISISAV LNSLVASVIC DVLFQIGQL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARID1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.58
Highest tissue expression
30 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 30 nTPM
  • bone marrow: 27 nTPM
  • parathyroid gland: 25 nTPM
  • thymus: 23 nTPM
  • tongue: 23 nTPM
  • skin: 21 nTPM

Single-cell type

  • pituitary stem cells: 1,048 nCPM
  • renal connecting tubule cells: 1,028 nCPM
  • myonuclei: 998 nCPM
  • distal convoluted tubule cells: 882 nCPM
  • lactotrophs: 867 nCPM
  • b-cells: 867 nCPM

Immune cell

  • plasmacytoid DC: 9.3 nTPM
  • naive B-cell: 6.8 nTPM
  • memory B-cell: 5.2 nTPM
  • basophil: 4.9 nTPM
  • neutrophil: 4.2 nTPM
  • gdT-cell: 4.1 nTPM

Brain region

  • cerebellum: 107 nTPM
  • hippocampal formation: 91 nTPM
  • cerebral cortex: 82 nTPM
  • white matter: 82 nTPM
  • amygdala: 79 nTPM
  • medulla oblongata: 78 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ARID1B.

Disease | AllUniProt

Conditions ARID1B is implicated in, by any mechanism.

Disease | GeneticClinVar

580 pathogenic / likely-pathogenic of 2,712 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.1
gnomAD pLI
1
gnomAD missense Z
2.59
DepMap mean gene effect
-0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ARID1B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARID1B as an antibody target. Whether an autoantibody or antibody against ARID1B could matter depends on whether native ARID1B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARID1B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARID1B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ARID1B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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