Metal-dependent hydrolase, composite domain superfamily
IPR011059
Definition
The composite domain of metal-dependent hydrolases has a pseudo-barrel fold that is interrupted by the catalytic β/α barrel domain. This domain is found in a variety of bacterial and fungal enzymes, including: cytosine deaminase, an enzyme that is important in the pyrimidine salvage pathway PMID:11812140; the alpha-subunit of urease, a virulence factor of gastric pathogens such as Helicobacter pylori (Campylobacter pylori) PMID:12127484; D- and L-hydantoinases (dihydropyrimidinase), which catalyse the production of D- and L-amino acids, respectively PMID:12837777; isoaspartyl dipeptidase from Escherichia coli, which functions in protein degradation PMID:12718528; N-acetylglucosamine-6-phosphate deacetylase, which is an enzyme from the biosynthetic pathway to amino-sugar-nucleotides PMID:14557261; and N-acyl-D-amino acid amidohydrolase (D-aminoacylase), involved in the synthesis of D-amino acids PMID:12454005.
10 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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