Seroatlas · Human Serome Atlas

DPYSL4

Dihydropyrimidinase-related protein 4

Also known as: CRMP3, DPYL4_HUMAN, DRP-4, ULIP4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O14531
Gene: DPYSL4
Ensembl: ENSG00000151640
Chromosome: 10
Canonical length: 572 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Vesicles,Mitochondria
Quaternary structure: Homotetramer

OverviewNCBI Gene

Enables filamin binding activity. Predicted to be involved in nervous system development. Predicted to be located in cytoplasm. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

572 residues, UniProt reviewed canonical sequence.

>O14531|DPYSL4
     1  MSFQGKKSIP RITSDRLLIR GGRIVNDDQS FYADVHVEDG LIKQIGENLI VPGGIKTIDA
    61  HGLMVLPGGV DVHTRLQMPV LGMTPADDFC QGTKAALAGG TTMILDHVFP DTGVSLLAAY
   121  EQWRERADSA ACCDYSLHVD ITRWHESIKE ELEALVKEKG VNSFLVFMAY KDRCQCSDSQ
   181  MYEIFSIIRD LGALAQVHAE NGDIVEEEQK RLLELGITGP EGHVLSHPEE VEAEAVYRAV
   241  TIAKQANCPL YVTKVMSKGA ADAIAQAKRR GVVVFGEPIT ASLGTDGSHY WSKNWAKAAA
   301  FVTSPPVNPD PTTADHLTCL LSSGDLQVTG SAHCTFTTAQ KAVGKDNFAL IPEGTNGIEE
   361  RMSMVWEKCV ASGKMDENEF VAVTSTNAAK IFNFYPRKGR VAVGSDADLV IWNPKATKII
   421  SAKTHNLNVE YNIFEGVECR GAPAVVISQG RVALEDGKMF VTPGAGRFVP RKTFPDFVYK
   481  RIKARNRLAE IHGVPRGLYD GPVHEVMVPA KPGSGAPARA SCPGKISVPP VRNLHQSGFS
   541  LSGSQADDHI ARRTAQKIMA PPGGRSNITS LS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DPYSL4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 34 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 34 nTPM
heart muscle: 33 nTPM
hippocampal formation: 26 nTPM
basal ganglia: 23 nTPM
amygdala: 22 nTPM
hypothalamus: 19 nTPM

Single-cell type

cone photoreceptor cells: 62 nCPM
retinal amacrine cells: 50 nCPM
retinal bipolar cells: 43 nCPM
retinal horizontal cells: 26 nCPM
brain inhibitory neurons: 19 nCPM
oligodendrocyte progenitor cells: 17 nCPM

Immune cell

naive CD4 T-cell: 0.5 nTPM
gdT-cell: 0.3 nTPM
NK-cell: 0.3 nTPM
memory CD4 T-cell: 0.2 nTPM
intermediate monocyte: 0.1 nTPM
naive B-cell: 0.1 nTPM

Brain region

hippocampal formation: 41 nTPM
cerebral cortex: 39 nTPM
amygdala: 38 nTPM
white matter: 36 nTPM
basal ganglia: 34 nTPM
thalamus: 33 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DPYSL4.

Disease | ImmuneIEDB

Conditions an epitope on DPYSL4 was assayed in.

melanoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.89
gnomAD pLI: 0
gnomAD missense Z: 1.15
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

nervous system development

Molecular functions

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DPYSL4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DPYSL4 as an antibody target. Whether an autoantibody or antibody against DPYSL4 could matter depends on whether native DPYSL4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DPYSL4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DPYSL4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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