Metal-dependent hydrolase

Definition

The structural landmark of the metallo-dependent hydrolases (the amidohydrolase superfamily) is a (β/α)8-barrel fold (TIM barrel fold) with transition metal ions bound inside the barrel [[cite:PMID:12714059], [cite:PMID:16277370]]. This enzyme group comprises hundreds of hydrolytic enzymes with a diverse spectrum of substrates and reactions. Members have mono- or binuclear active-site metal centres, and play key roles in many fundamental processes [[cite:PMID:15850372], [cite:PMID:16171387]].

24 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (24 proteins: gene, accession, name)

• ACMSD
• ADA
• ADA2
• AMDHD1
• AMDHD2
• AMPD1
• AMPD2
• AMPD3
• CAD
• CRMP1
• DPEP1
• DPEP2
• DPEP3
• DPYS
• DPYSL2
• DPYSL3
• DPYSL4
• DPYSL5
• GDA
• MAPDA
• PTER
• TATDN1
• TATDN2
• TATDN3