Seroatlas · Human Serome Atlas

DPYSL5

Dihydropyrimidinase-related protein 5

Also known as: CRAM, CRMP-5, CRMP5, CV2, DPYL5_HUMAN, Ulip6

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BPU6
Gene
DPYSL5
Ensembl
ENSG00000157851
Chromosome
2
Canonical length
564 aa
Protein class
Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol
Quaternary structure
Homotetramer

OverviewNCBI Gene

This gene encodes a member of the CRMP (collapsing response mediator protein) family thought to be involved in neural development. Antibodies to the encoded protein were found in some patients with neurologic symptoms who had paraneoplastic syndrome. A pseudogene of this gene is found on chromosome 11. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011]

Canonical amino-acid sequenceUniProt

564 residues, UniProt reviewed canonical sequence.

>Q9BPU6|DPYSL5
     1  MLANSASVRI LIKGGKVVND DCTHEADVYI ENGIIQQVGR ELMIPGGAKV IDATGKLVIP
    61  GGIDTSTHFH QTFMNATCVD DFYHGTKAAL VGGTTMIIGH VLPDKETSLV DAYEKCRGLA
   121  DPKVCCDYAL HVGITWWAPK VKAEMETLVR EKGVNSFQMF MTYKDLYMLR DSELYQVLHA
   181  CKDIGAIARV HAENGELVAE GAKEALDLGI TGPEGIEISR PEELEAEATH RVITIANRTH
   241  CPIYLVNVSS ISAGDVIAAA KMQGKVVLAE TTTAHATLTG LHYYHQDWSH AAAYVTVPPL
   301  RLDTNTSTYL MSLLANDTLN IVASDHRPFT TKQKAMGKED FTKIPHGVSG VQDRMSVIWE
   361  RGVVGGKMDE NRFVAVTSSN AAKLLNLYPR KGRIIPGADA DVVVWDPEAT KTISASTQVQ
   421  GGDFNLYENM RCHGVPLVTI SRGRVVYENG VFMCAEGTGK FCPLRSFPDT VYKKLVQREK
   481  TLKVRGVDRT PYLGDVAVVV HPGKKEMGTP LADTPTRPVT RHGGMRDLHE SSFSLSGSQI
   541  DDHVPKRASA RILAPPGGRS SGIW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DPYSL5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
129 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 129 nTPM
  • midbrain: 45 nTPM
  • basal ganglia: 44 nTPM
  • hypothalamus: 29 nTPM
  • hippocampal formation: 25 nTPM
  • cerebellum: 20 nTPM

Single-cell type

  • cone photoreceptor cells: 364 nCPM
  • oligodendrocytes: 328 nCPM
  • late spermatids: 254 nCPM
  • bergmann glia: 140 nCPM
  • retinal ganglion cells: 128 nCPM
  • brain inhibitory neurons: 125 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • white matter: 228 nTPM
  • medulla oblongata: 166 nTPM
  • pons: 137 nTPM
  • thalamus: 125 nTPM
  • cerebellum: 124 nTPM
  • spinal cord: 113 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DPYSL5.

Disease | AllUniProt

Conditions DPYSL5 is implicated in, by any mechanism.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 132 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Ritscher-Schinzel syndrome 4
  • DPYSL5-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.11
gnomAD pLI
1
gnomAD missense Z
3.08
DepMap mean gene effect
-0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

  • in cyclic amides
  • hydrolase activity
  • acting on carbon-nitrogen (but not peptide) bonds

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DPYSL5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DPYSL5 as an antibody target. Whether an autoantibody or antibody against DPYSL5 could matter depends on whether native DPYSL5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DPYSL5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Source-annotated serology context

The source annotations explicitly mention antibody, autoantibody, autoantigen, or autoimmune context. This is biological context, not study-specific reactivity.

  • Antibodies to the encoded protein were found in some patients with neurologic symptoms who had paraneoplastic syndrome.

Canonical record: https://seroatlas.com/gene/DPYSL5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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