DPYSL3

Protein identityUniProt · HPA

UniProt accession

Q14195

Gene

DPYSL3

Ensembl

ENSG00000113657

Chromosome

5

Canonical length

570 aa

Protein class

Predicted intracellular proteins

Subcellular location

Cytosol

Quaternary structure

Homotetramer

OverviewNCBI Gene

Enables filamin binding activity. Predicted to be involved in several processes, including actin filament organization; regulation of plasma membrane bounded cell projection organization; and response to axon injury. Predicted to act upstream of or within nervous system development. Predicted to be located in several cellular components, including exocytic vesicle; growth cone; and lamellipodium. Predicted to be part of filamentous actin. Predicted to be active in cytosol and synapse. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

570 residues, UniProt reviewed canonical sequence.

>Q14195|DPYSL3
     1  MSYQGKKNIP RITSDRLLIK GGRIVNDDQS FYADIYMEDG LIKQIGDNLI VPGGVKTIEA
    61  NGKMVIPGGI DVHTHFQMPY KGMTTVDDFF QGTKAALAGG TTMIIDHVVP EPESSLTEAY
   121  EKWREWADGK SCCDYALHVD ITHWNDSVKQ EVQNLIKDKG VNSFMVYMAY KDLYQVSNTE
   181  LYEIFTCLGE LGAIAQVHAE NGDIIAQEQT RMLEMGITGP EGHVLSRPEE LEAEAVFRAI
   241  TIASQTNCPL YVTKVMSKSA ADLISQARKK GNVVFGEPIT ASLGIDGTHY WSKNWAKAAA
   301  FVTSPPLSPD PTTPDYINSL LASGDLQLSG SAHCTFSTAQ KAIGKDNFTA IPEGTNGVEE
   361  RMSVIWDKAV ATGKMDENQF VAVTSTNAAK IFNLYPRKGR ISVGSDSDLV IWDPDAVKIV
   421  SAKNHQSAAE YNIFEGMELR GAPLVVICQG KIMLEDGNLH VTQGAGRFIP CSPFSDYVYK
   481  RIKARRKMAD LHAVPRGMYD GPVFDLTTTP KGGTPAGSAR GSPTRPNPPV RNLHQSGFSL
   541  SGTQVDEGVR SASKRIVAPP GGRSNITSLS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DPYSL3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.28

Highest tissue expression

203 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.22

gnomAD pLI

1

gnomAD missense Z

2.48

DepMap mean gene effect

0.11

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• actin crosslink formation
• actin filament bundle assembly
• cellular response to cytokine stimulus
• negative regulation of cell migration
• negative regulation of neuron projection development
• neuron development
• positive regulation of filopodium assembly
• positive regulation of neuron projection development
• response to axon injury

Molecular functions

• chondroitin sulfate binding
• filamin binding
• hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
• identical protein binding
• phosphoprotein binding
• SH3 domain binding

Cellular components

• cell body
• cytosol
• exocytic vesicle
• extracellular space
• filamentous actin
• growth cone
• lamellipodium
• synapse

Protein domainsUniProt · Pfam · InterPro

• Amidohydrolase-related
• Metal-dependent hydrolase, composite domain superfamily
• Hydantoinase/dihydropyrimidinase
• Metal-dependent hydrolase
• Metallo-dependent Hydrolases Superfamily
• Amidohydrolase family

KeywordsUniProt

• Cell projection
• Cytoplasm
• Phosphoprotein

InteractionsUniProt · HPA

Protein binding partners of DPYSL3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• FLNA
• DPYSL5
• DPYSL2