Amidohydrolase family
PF01979
Definition
This family of enzymes are a a large metal dependent hydrolase superfamily PMID:9144792. The family includes Adenine deaminase [ec:3.5.4.2] that hydrolyses adenine to form hypoxanthine and ammonia. Adenine deaminases reaction is important for adenine utilisation as a purine and also as a nitrogen source PMID:8550522. This family also includes dihydroorotase and N-acetylglucosamine-6-phosphate deacetylases, [ec:3.5.1.25] These enzymes catalyse the reaction N-acetyl-D-glucosamine 6-phosphate + H2O D-glucosamine 6-phosphate + acetate. This family includes the catalytic domain of urease alpha subunit PMID:7754395. Dihydroorotases ([ec:3.5.2.3]) are also included [[cite:PMID:9878395],[cite:PMID:8590465]].
10 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
Loading the interactive Seroatlas explorer...