Metallo-dependent Hydrolases Superfamily
IPR050378
Definition
The Metallo-dependent Hydrolases family encompasses enzymes that catalyze a variety of hydrolytic reactions, often involving cyclic amide bonds. Members of this family are involved in diverse biological processes, including the degradation of dihydropyrimidines, the hydrolysis of D-hydantoin derivatives, and the regulation of cytoskeletal dynamics. Some proteins within this family are necessary for axon guidance and neuronal growth cone collapse, playing a crucial role in neuronal development and cell migration. Others are implicated in the reductive pyrimidine degradation pathway, converting dihydropyrimidines to N-carbamyl-amino acids. Additionally, certain family members participate in the negative regulation of dendrite outgrowth. The family also includes uncharacterized proteins that may have roles in cellular metabolism and signaling.
6 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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