Seroatlas · Human Serome Atlas

DLGAP1

Disks large-associated protein 1

Also known as: DAP-1, DLGP1_HUMAN, GKAP, SAPAP1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O14490
Gene
DLGAP1
Ensembl
ENSG00000170579
Chromosome
18
Canonical length
977 aa
Protein class
Predicted intracellular proteins
Subcellular location
Vesicles,Cytosol

OverviewNCBI Gene

Predicted to enable molecular adaptor activity. Predicted to be a structural constituent of postsynaptic density. Predicted to be involved in several processes, including aggresome assembly; protein localization to synapse; and regulation of proteasomal protein catabolic process. Predicted to be located in plasma membrane. Predicted to be active in glutamatergic synapse and postsynaptic density, intracellular component. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

977 residues, UniProt reviewed canonical sequence.

>O14490|DLGAP1
     1  MKGLSGSRSH HHGVTCDSAC DSLSHHSDRK PYLLSPVEHH PADHPYYTQR NSFQAECVGP
    61  FSDPLASSTF PRRHYTSQQE LKDECALVPR TLATKANRIP ANLLDQFERQ LPLSRDGYHT
   121  LQYKRTAVEH RSDSPGRIRH LVHSVQKLFT KSHSLEGPSK GSVNGGKASP DEAQAARYGK
   181  RSKSKERRAE PKARPSTSPG WWSSDDNLDG DMCIYHAPSG VMTMGRCPDR SASQYFLEAY
   241  NTISEQAVKA SRSNNDVKCS TCANLPVSLD TPLLKKSAWS STLTVSRARE VYQKASVNMD
   301  QAMVKSESCQ QERSCQYLQV PQDEWTGYTP RGKDDEIPCR RMRSGSYIKA MGDEDSGDSD
   361  TSPKPSPKVA ARRESYLKAT QPSLTELTTL KISNEHSPKL QIRSHSYLRA VSEVSINRSL
   421  DSLDPAGLLT SPKFRSRNES YMRAMSTISQ VSEMEVNGQF ESVCESVFSE LESQAVEALD
   481  LPMPGCFRMR SHSYVRAIEK GCSQDDECVS LRSSSPPRTT TTVRTIQSST VSSCITTYKK
   541  TPPPVPPRTT TKPFISITAQ SSTESAQDAY MDGQGQRGDI ISQSGLSNST ESLDSMKALT
   601  AAIEAANAQI HGPASQHMGN NTATVTTTTT IATVTTEDRK KDHFKKNRCL SIGIQVDDAE
   661  EPDKTGENKA PSKFQSVGVQ VEEEKCFRRF TRSNSVTTAV QADLDFHDNL ENSLESIEDN
   721  SCPGPMARQF SRDASTSTVS IQGSGNHYHA CAADDDFDTD FDPSILPPPD PWIDSITEDP
   781  LEAVQRSVCH RDGHWFLKLL QAERDRMEGW CQQMEREERE NNLPEDILGK IRTAVGSAQL
   841  LMAQKFYQFR ELCEENLNPN AHPRPTSQDL AGFWDMLQLS IENISMKFDE LHQLKANNWK
   901  QMDPLDKKER RAPPPVPKKP AKGPAPLIRE RSLESSQRQE ARKRLMAAKR AASVRQNSAT
   961  ESAESIEIYI PEAQTRL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DLGAP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.64
Highest tissue expression
52 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 52 nTPM
  • cerebellum: 34 nTPM
  • hippocampal formation: 21 nTPM
  • amygdala: 18 nTPM
  • basal ganglia: 12 nTPM
  • seminal vesicle: 9.5 nTPM

Single-cell type

  • pituicytes/fscs: 3,341 nCPM
  • brain inhibitory neurons: 3,103 nCPM
  • retinal amacrine cells: 2,893 nCPM
  • brain excitatory neurons: 2,524 nCPM
  • sertoli cells: 2,069 nCPM
  • oligodendrocyte progenitor cells: 1,645 nCPM

Immune cell

  • eosinophil: 0.3 nTPM
  • basophil: 0.2 nTPM
  • classical monocyte: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 210 nTPM
  • hippocampal formation: 158 nTPM
  • white matter: 141 nTPM
  • basal ganglia: 139 nTPM
  • amygdala: 115 nTPM
  • cerebellum: 112 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.25
gnomAD pLI
1
gnomAD missense Z
3.2
DepMap mean gene effect
0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DLGAP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DLGAP1 as an antibody target. Whether an autoantibody or antibody against DLGAP1 could matter depends on whether native DLGAP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DLGAP1 is annotated at the cell surface, where native DLGAP1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label DLGAP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DLGAP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...