Seroatlas · Human Serome Atlas

LIN7B

Protein lin-7 homolog B

Also known as: LIN-7B, LIN7B_HUMAN, MALS-2, VELI2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HAP6
Gene: LIN7B
Ensembl: ENSG00000104863
Chromosome: 19
Canonical length: 207 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Enables protein domain specific binding activity. Predicted to be involved in neurotransmitter secretion; regulation of synaptic assembly at neuromuscular junction; and synaptic vesicle transport. Predicted to be located in plasma membrane. Predicted to be part of MPP7-DLG1-LIN7 complex. Predicted to be active in basolateral plasma membrane; cell-cell junction; and postsynaptic density, intracellular component. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

207 residues, UniProt reviewed canonical sequence.

>Q9HAP6|LIN7B
     1  MAALVEPLGL ERDVSRAVEL LERLQRSGEL PPQKLQALQR VLQSRFCSAI REVYEQLYDT
    61  LDITGSAEIR AHATAKATVA AFTASEGHAH PRVVELPKTD EGLGFNIMGG KEQNSPIYIS
   121  RVIPGGVADR HGGLKRGDQL LSVNGVSVEG EQHEKAVELL KAAQGSVKLV VRYTPRVLEE
   181  MEARFEKMRS ARRRQQHQSY SSLESRG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LIN7B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 51 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 51 nTPM
skeletal muscle: 50 nTPM
hypothalamus: 50 nTPM
amygdala: 49 nTPM
cerebral cortex: 47 nTPM
hippocampal formation: 40 nTPM

Single-cell type

undifferentiated spermatogonia: 108 nCPM
esophageal apical cells: 103 nCPM
oocytes: 65 nCPM
differentiating spermatogonia: 61 nCPM
esophageal suprabasal cells: 50 nCPM
epididymal principal cells: 38 nCPM

Immune cell

plasmacytoid DC: 12 nTPM
naive CD4 T-cell: 7 nTPM
gdT-cell: 6.4 nTPM
naive CD8 T-cell: 6.1 nTPM
MAIT T-cell: 5.1 nTPM
memory CD4 T-cell: 5.1 nTPM

Brain region

hypothalamus: 36 nTPM
cerebral cortex: 34 nTPM
basal ganglia: 27 nTPM
medulla oblongata: 27 nTPM
thalamus: 26 nTPM
pons: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.44
gnomAD pLI: 0.85
gnomAD missense Z: 1.08
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LIN7B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LIN7B as an antibody target. Whether an autoantibody or antibody against LIN7B could matter depends on whether native LIN7B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LIN7B is annotated at the cell surface, where native LIN7B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LIN7B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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