CFAP126
Protein Flattop
Also known as: C1orf192, Flattop, FLTOP_HUMAN, Fltp
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q5VTH2
- Gene
- CFAP126
- Ensembl
- ENSG00000188931
- Chromosome
- 1
- Canonical length
- 177 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Vesicles,Plasma membrane,Primary cilium,Cytosol,Mid piece,Principal piece
OverviewNCBI Gene
Predicted to be involved in cilium organization and flagellated sperm motility. Located in several cellular components, including axonemal microtubule; cytosol; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]
Canonical amino-acid sequenceUniProt
177 residues, UniProt reviewed canonical sequence.
>Q5VTH2|CFAP126
1 MATNYSANQY EKAFSSKYLQ NWSPTKPTKE SISSHEGYTQ IIANDRGHLL PSVPRSKANP
61 WGSFMGTWQM PLKIPPARVT LTSRTTAGAA SLTKWIQKNP DLLKASNGLC PEILGKPHDP
121 DSQKKLRKKS ITKTVQQARS PTIIPSSPAA NLNSPDELQS SHPSAGHTPG PQRPAKSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CFAP126 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.58
- Highest tissue expression
- 202 nTPM
Expression across tissuesHPA
Tissue
- choroid plexus: 202 nTPM
- fallopian tube: 143 nTPM
- skeletal muscle: 79 nTPM
- heart muscle: 37 nTPM
- retina: 30 nTPM
- cerebral cortex: 27 nTPM
Single-cell type
- fallopian tube ciliated cells: 544 nCPM
- epididymal efferent duct ciliated cells: 477 nCPM
- respiratory ciliated cells: 388 nCPM
- endometrial ciliated cells: 239 nCPM
- late primary spermatocytes: 162 nCPM
- early spermatids: 68 nCPM
Immune cell
- naive B-cell: 0.5 nTPM
- intermediate monocyte: 0.4 nTPM
- eosinophil: 0.3 nTPM
- memory CD4 T-cell: 0.3 nTPM
- memory CD8 T-cell: 0.3 nTPM
- naive CD4 T-cell: 0.3 nTPM
Brain region
- choroid plexus: 132 nTPM
- thalamus: 98 nTPM
- white matter: 98 nTPM
- medulla oblongata: 98 nTPM
- midbrain: 97 nTPM
- spinal cord: 91 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.69
- gnomAD pLI
- 0
- DepMap mean gene effect
- -0.07
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Protein Flattop
- Flattop
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of CFAP126 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CFAP126 as an antibody target. Whether an autoantibody or antibody against CFAP126 could matter depends on whether native CFAP126 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CFAP126 is annotated at the cell surface, where native CFAP126 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label CFAP126 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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