CADM3

Protein identityUniProt · HPA

UniProt accession

Q8N126

Gene

CADM3

Ensembl

ENSG00000162706

Chromosome

1

Canonical length

398 aa

Protein class

Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins

Secretome location

Intracellular and membrane

Quaternary structure

Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a calcium-independent cell-cell adhesion protein that can form homodimers or heterodimers with other nectin proteins. The encoded protein has both homophilic and heterophilic cell-cell adhesion activity. This gene is reported to be a tumor suppressor gene. [provided by RefSeq, Oct 2016]

Canonical amino-acid sequenceUniProt

398 residues, UniProt reviewed canonical sequence.

>Q8N126|CADM3
     1  MGAPAASLLL LLLLFACCWA PGGANLSQDD SQPWTSDETV VAGGTVVLKC QVKDHEDSSL
    61  QWSNPAQQTL YFGEKRALRD NRIQLVTSTP HELSISISNV ALADEGEYTC SIFTMPVRTA
   121  KSLVTVLGIP QKPIITGYKS SLREKDTATL NCQSSGSKPA ARLTWRKGDQ ELHGEPTRIQ
   181  EDPNGKTFTV SSSVTFQVTR EDDGASIVCS VNHESLKGAD RSTSQRIEVL YTPTAMIRPD
   241  PPHPREGQKL LLHCEGRGNP VPQQYLWEKE GSVPPLKMTQ ESALIFPFLN KSDSGTYGCT
   301  ATSNMGSYKA YYTLNVNDPS PVPSSSSTYH AIIGGIVAFI VFLLLIMLIF LGHYLIRHKG
   361  TYLTHEAKGS DDAPDADTAI INAEGGQSGG DDKKEYFI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CADM3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.39

Highest tissue expression

323 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CADM3.

Disease | AllUniProt

Conditions CADM3 is implicated in, by any mechanism.

• Charcot-Marie-Tooth disease, axonal, type 2FF (CMT2FF) MIM:619519

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 91 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Charcot-Marie-Tooth disease, axonal, type 2FF

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.36

gnomAD pLI

0.93

gnomAD missense Z

1.69

DepMap mean gene effect

0.06

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
• homophilic cell adhesion via plasma membrane adhesion molecules

Molecular functions

• protein homodimerization activity

Cellular components

• cell-cell junction
• plasma membrane
• presynaptic membrane

Protein domainsUniProt · Pfam · InterPro

• Neurexin/syndecan/glycophorin C
• Immunoglobulin subtype 2
• Immunoglobulin domain subtype
• Immunoglobulin-like domain
• Immunoglobulin V-set domain
• CD80-like, immunoglobulin C2-set
• Immunoglobulin-like fold
• Immunoglobulin-like domain superfamily
• Immunoglobulin V-set domain
• CD80-like C2-set immunoglobulin domain
• Immunoglobulin domain

KeywordsUniProt

• Calcium
• Cell adhesion
• Cell junction
• Cell membrane
• Charcot-Marie-Tooth disease
• Disulfide bond
• Glycoprotein
• Immunoglobulin domain
• Membrane
• Neurodegeneration
• Neuropathy
• Phosphoprotein
• Repeat
• Signal
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of CADM3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CASK
• DLG3
• EPB41L1
• PALS2