Rossmann-like alpha/beta/alpha sandwich fold
IPR014729
Definition
This superfamily represents domains related by a common ancestor that have a Rossmann-like, 3-layer, α/β/α sandwich fold. Protein families in which the domain is found include: Nucleotidylyl transferases ([ec:2.7.7]) such as cytidylyltransferases PMID:16344011, adenylyltransferases PMID:14684898. Class I aminoacyl-tRNA synthetases (catalytic domain), such as tyrosyl-tRNA synthetase ([ec:6.1.1.1]) and glutaminyl-tRNA synthetase ([ec:6.1.1.18]) PMID:7701318. Pantothenate synthetases ([ec:6.3.2.1]) PMID:16460002. ATP sulphurylase (central domain) PMID:16387658 N-type ATP pyrophosphatases, such as beta-lactam synthetase ([ec:6.3.3.4]) and GMP synthase ([ec:6.3.5.2]) PMID:8548458. PP-loop ATPases such as the cell cycle protein MesJ (N-terminal domain) PMID:15894617. Phosphoadenylyl sulphate (PAPS) reductase PMID:9261082 Electron transfer flavoprotein (ETFP) subunits, such as the N-terminal domains of the alpha and beta subunits PMID:8962055. Universal stress protein A (UspA) PMID:16952944. Cryptochrome and DNA photolyase PMID:17101984.
42 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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