Seroatlas · Human Serome Atlas

PPARD

Peroxisome proliferator-activated receptor delta

Also known as: FAAR, NR1C2, NUC1, NUCII, PPARB, PPARD_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q03181
Gene
PPARD
Ensembl
ENSG00000112033
Chromosome
6
Canonical length
441 aa
Protein class
FDA approved drug targets, Nuclear receptors, Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. The encoded protein is thought to function as an integrator of transcriptional repression and nuclear receptor signaling. It may inhibit the ligand-induced transcriptional activity of peroxisome proliferator activated receptors alpha and gamma, though evidence for this effect is inconsistent. Expression of this gene in colorectal cancer cells may be variable but is typically relatively low. Knockout studies in mice suggested a role for this protein in myelination of the corpus callosum, lipid metabolism, differentiation, and epidermal cell proliferation. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. [provided by RefSeq, Aug 2017]

Canonical amino-acid sequenceUniProt

441 residues, UniProt reviewed canonical sequence.

>Q03181|PPARD
     1  MEQPQEEAPE VREEEEKEEV AEAEGAPELN GGPQHALPSS SYTDLSRSSS PPSLLDQLQM
    61  GCDGASCGSL NMECRVCGDK ASGFHYGVHA CEGCKGFFRR TIRMKLEYEK CERSCKIQKK
   121  NRNKCQYCRF QKCLALGMSH NAIRFGRMPE AEKRKLVAGL TANEGSQYNP QVADLKAFSK
   181  HIYNAYLKNF NMTKKKARSI LTGKASHTAP FVIHDIETLW QAEKGLVWKQ LVNGLPPYKE
   241  ISVHVFYRCQ CTTVETVREL TEFAKSIPSF SSLFLNDQVT LLKYGVHEAI FAMLASIVNK
   301  DGLLVANGSG FVTREFLRSL RKPFSDIIEP KFEFAVKFNA LELDDSDLAL FIAAIILCGD
   361  RPGLMNVPRV EAIQDTILRA LEFHLQANHP DAQYLFPKLL QKMADLRQLV TEHAQMMQRI
   421  KKTETETSLH PLLQEIYKDM Y

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPARD can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
45 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 45 nTPM
  • thyroid gland: 39 nTPM
  • hippocampal formation: 35 nTPM
  • cerebral cortex: 33 nTPM
  • vagina: 33 nTPM
  • liver: 32 nTPM

Single-cell type

  • syncytiotrophoblasts: 371 nCPM
  • pancreatic acinar cells: 320 nCPM
  • urothelial cells: 282 nCPM
  • esophageal apical cells: 278 nCPM
  • mast cells: 268 nCPM
  • monocytes: 246 nCPM

Immune cell

  • eosinophil: 3.3 nTPM
  • neutrophil: 2.3 nTPM
  • naive CD4 T-cell: 2.1 nTPM
  • naive CD8 T-cell: 2.1 nTPM
  • naive B-cell: 1.6 nTPM
  • classical monocyte: 1.5 nTPM

Brain region

  • thalamus: 61 nTPM
  • hippocampal formation: 58 nTPM
  • cerebral cortex: 55 nTPM
  • amygdala: 51 nTPM
  • midbrain: 50 nTPM
  • pons: 49 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.19
gnomAD pLI
0.99
gnomAD missense Z
2.48
DepMap mean gene effect
0
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PPARD in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPARD as an antibody target. Whether an autoantibody or antibody against PPARD could matter depends on whether native PPARD is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPARD is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPARD as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PPARD. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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