Seroatlas · Human Serome Atlas

FBXL21P

Putative F-box/LRR-repeat protein 21

Also known as: FXL21_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UKT6
Gene: FBXL21P
Canonical length: 434 aa

OverviewNCBI Gene

No narrative summary is available for FBXL21P in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

434 residues, UniProt reviewed canonical sequence.

>Q9UKT6|FBXL21P
     1  MKRNSLSVEN KIVQLSGAAK QPKVGFYSSL NQTHTHTVLL DWGSLPHHVV LQIFQYLPLL
    61  DRACASSVCR RWNEVFHISD LWRKFEFELN QSATSSFKST HPDLIQQIIK KHFAHLQYVS
   121  FKVDSSAESA EAACDILSQL VNCSIQTLGL ISTAKPSFMN VSESHFVSAL TVVFINSKSL
   181  SSIKIEDTPV DDPSLKILVA NNSDTLRLPK MSSCPHVSSD GILCVADRCQ GLRELALNYY
   241  ILTDELFLAL SSETHVNLEH LRIDVVSENP GQIKFHAVKK HSWDALIKHS PRVNVVMHFF
   301  LYEEEFETFF KEETPVTHLY FGRSVSKVVL GRVGLNCPRL IELVVCANDL QPLDNELICI
   361  AEHCTNLTAL GLSKCEVSCS AFIRFVRLCE RRLTQLSVME EVLIPDEDYS LDEIHTEVSK
   421  YLGRVWFPDV MPLW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FBXL21P can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

ubiquitin-protein transferase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FBXL21P in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FBXL21P as an antibody target. Whether an autoantibody or antibody against FBXL21P could matter depends on whether native FBXL21P is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FBXL21P is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FBXL21P as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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