Seroatlas · Human Serome Atlas

FBXL3

F-box/LRR-repeat protein 3

Also known as: FBL3, FBL3A, FBXL3_HUMAN, FBXL3A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UKT7
Gene
FBXL3
Ensembl
ENSG00000005812
Chromosome
13
Canonical length
428 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nuclear bodies

OverviewNCBI Gene

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats and is localized in the nucleus. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

428 residues, UniProt reviewed canonical sequence.

>Q9UKT7|FBXL3
     1  MKRGGRDSDR NSSEEGTAEK SKKLRTTNEH SQTCDWGNLL QDIILQVFKY LPLLDRAHAS
    61  QVCRNWNQVF HMPDLWRCFE FELNQPATSY LKATHPELIK QIIKRHSNHL QYVSFKVDSS
   121  KESAEAACDI LSQLVNCSLK TLGLISTARP SFMDLPKSHF ISALTVVFVN SKSLSSLKID
   181  DTPVDDPSLK VLVANNSDTL KLLKMSSCPH VSPAGILCVA DQCHGLRELA LNYHLLSDEL
   241  LLALSSEKHV RLEHLRIDVV SENPGQTHFH TIQKSSWDAF IRHSPKVNLV MYFFLYEEEF
   301  DPFFRYEIPA THLYFGRSVS KDVLGRVGMT CPRLVELVVC ANGLRPLDEE LIRIAERCKN
   361  LSAIGLGECE VSCSAFVEFV KMCGGRLSQL SIMEEVLIPD QKYSLEQIHW EVSKHLGRVW
   421  FPDMMPTW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FBXL3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
65 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 65 nTPM
  • blood vessel: 52 nTPM
  • thyroid gland: 45 nTPM
  • adipose tissue: 43 nTPM
  • ovary: 41 nTPM
  • breast: 40 nTPM

Single-cell type

  • cardiomyocytes: 168 nCPM
  • neutrophils: 164 nCPM
  • neutrophil progenitors: 138 nCPM
  • vascular smooth muscle cells: 96 nCPM
  • peritubular myoid cells: 90 nCPM
  • pericytes: 85 nCPM

Immune cell

  • basophil: 8 nTPM
  • neutrophil: 5.2 nTPM
  • T-reg: 5.1 nTPM
  • eosinophil: 4.6 nTPM
  • naive CD4 T-cell: 4.5 nTPM
  • memory CD4 T-cell: 3.8 nTPM

Brain region

  • white matter: 56 nTPM
  • cerebellum: 48 nTPM
  • basal ganglia: 41 nTPM
  • spinal cord: 38 nTPM
  • medulla oblongata: 37 nTPM
  • amygdala: 37 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FBXL3.

Disease | AllUniProt

Conditions FBXL3 is implicated in, by any mechanism.

  • Intellectual developmental disorder with short stature, facial anomalies, and speech defects (IDDSFAS) MIM:606220

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 46 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Intellectual disability, short stature, facial anomalies, and joint dislocations

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.29
gnomAD pLI
0.98
gnomAD missense Z
2.83
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FBXL3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FBXL3 as an antibody target. Whether an autoantibody or antibody against FBXL3 could matter depends on whether native FBXL3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FBXL3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FBXL3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FBXL3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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