Seroatlas · Human Serome Atlas

XRN2

5'-3' exoribonuclease 2

Also known as: XRN2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H0D6
Gene: XRN2
Ensembl: ENSG00000088930
Chromosome: 20
Canonical length: 950 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

This gene encodes a 5'-3' exonuclease that promotes transcription termination at cotranscriptional cleavage sites. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

Canonical amino-acid sequenceUniProt

950 residues, UniProt reviewed canonical sequence.

>Q9H0D6|XRN2
     1  MGVPAFFRWL SRKYPSIIVN CVEEKPKECN GVKIPVDASK PNPNDVEFDN LYLDMNGIIH
    61  PCTHPEDKPA PKNEDEMMVA IFEYIDRLFS IVRPRRLLYM AIDGVAPRAK MNQQRSRRFR
   121  ASKEGMEAAV EKQRVREEIL AKGGFLPPEE IKERFDSNCI TPGTEFMDNL AKCLRYYIAD
   181  RLNNDPGWKN LTVILSDASA PGEGEHKIMD YIRRQRAQPN HDPNTHHCLC GADADLIMLG
   241  LATHEPNFTI IREEFKPNKP KPCGLCNQFG HEVKDCEGLP REKKGKHDEL ADSLPCAEGE
   301  FIFLRLNVLR EYLERELTMA SLPFTFDVER SIDDWVFMCF FVGNDFLPHL PSLEIRENAI
   361  DRLVNIYKNV VHKTGGYLTE SGYVNLQRVQ MIMLAVGEVE DSIFKKRKDD EDSFRRRQKE
   421  KRKRMKRDQP AFTPSGILTP HALGSRNSPG SQVASNPRQA AYEMRMQNNS SPSISPNTSF
   481  TSDGSPSPLG GIKRKAEDSD SEPEPEDNVR LWEAGWKQRY YKNKFDVDAA DEKFRRKVVQ
   541  SYVEGLCWVL RYYYQGCASW KWYYPFHYAP FASDFEGIAD MPSDFEKGTK PFKPLEQLMG
   601  VFPAASGNFL PPSWRKLMSD PDSSIIDFYP EDFAIDLNGK KYAWQGVALL PFVDERRLRA
   661  ALEEVYPDLT PEETRRNSLG GDVLFVGKHH PLHDFILELY QTGSTEPVEV PPELCHGIQG
   721  KFSLDEEAIL PDQIVCSPVP MLRDLTQNTV VSINFKDPQF AEDYIFKAVM LPGARKPAAV
   781  LKPSDWEKSS NGRQWKPQLG FNRDRRPVHL DQAAFRTLGH VMPRGSGTGI YSNAAPPPVT
   841  YQGNLYRPLL RGQAQIPKLM SNMRPQDSWR GPPPLFQQQR FDRGVGAEPL LPWNRMLQTQ
   901  NAAFQPNQYQ MLAGPGGYPP RRDDRGGRQG YPREGRKYPL PPPSGRYNWN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against XRN2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 69 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 69 nTPM
thymus: 44 nTPM
urinary bladder: 44 nTPM
tonsil: 43 nTPM
parathyroid gland: 43 nTPM
lymph node: 40 nTPM

Single-cell type

neutrophils: 514 nCPM
monocytes: 271 nCPM
monocyte progenitors: 236 nCPM
neutrophil progenitors: 233 nCPM
endometrial ciliated cells: 194 nCPM
endometrial glandular cells: 187 nCPM

Immune cell

non-classical monocyte: 72 nTPM
neutrophil: 69 nTPM
classical monocyte: 69 nTPM
myeloid DC: 61 nTPM
intermediate monocyte: 55 nTPM
total PBMC: 54 nTPM

Brain region

choroid plexus: 38 nTPM
cerebellum: 32 nTPM
white matter: 31 nTPM
medulla oblongata: 29 nTPM
basal ganglia: 29 nTPM
hypothalamus: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.36
gnomAD pLI: 0.35
gnomAD missense Z: 2.5
DepMap mean gene effect: -1.15
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of XRN2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads XRN2 as an antibody target. Whether an autoantibody or antibody against XRN2 could matter depends on whether native XRN2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

XRN2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label XRN2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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