Seroatlas · Human Serome Atlas

CIART

Circadian-associated transcriptional repressor

Also known as: BC017397, C1orf51, CHRONO, CIART_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N365
Gene: CIART
Ensembl: ENSG00000159208
Chromosome: 1
Canonical length: 385 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable E-box binding activity. Predicted to be involved in circadian regulation of gene expression; locomotor rhythm; and negative regulation of DNA-templated transcription. Predicted to be located in PML body. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

385 residues, UniProt reviewed canonical sequence.

>Q8N365|CIART
     1  MDSPSSVSSY SSYSLSSSFP TSPVNSDFGF PSDSEREDKG AHGPRPDTVG QRGGSRPSPG
    61  PIRCRHRSKV SGNQHTPSHP KQRGSASPMA GSGAKRSRDG ELETSLNTQG CTTEGDLLFA
   121  QKCKELQGFI PPLTDLLNGL KMGRFERGLS SFQQSVAMDR IQRIVGVLQK PQMGERYLGT
   181  LLQVEGMLKT WFPQIAAQKS SLGGGKHQLT KHFPSHHSDS AASSPASPME KMDQTQLGHL
   241  ALKPKQPWHL TQWPAMNLTW IHTTPICNPP LSSPGTISFS HGPLGTGTGI GVILFLQHGV
   301  QPFTHSAPTT PVPPTTASPV IPGEPMKLSG EGPRCYSLPV TLPSDWSYTL SPPSLPTLAR
   361  KMTIGHREQQ RSHPPVAADA HLLNL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CIART can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 51 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 51 nTPM
tongue: 43 nTPM
skin: 39 nTPM
parathyroid gland: 30 nTPM
basal ganglia: 28 nTPM
heart muscle: 28 nTPM

Single-cell type

oocytes: 143 nCPM
cone photoreceptor cells: 46 nCPM
müller glia: 32 nCPM
epididymal efferent duct ciliated cells: 31 nCPM
retinal bipolar cells: 26 nCPM
epididymal efferent duct absorptive cells: 24 nCPM

Immune cell

memory CD4 T-cell: 1.4 nTPM
MAIT T-cell: 1.2 nTPM
naive CD4 T-cell: 0.8 nTPM
naive CD8 T-cell: 0.4 nTPM
gdT-cell: 0.1 nTPM
T-reg: 0.1 nTPM

Brain region

basal ganglia: 28 nTPM
cerebellum: 24 nTPM
choroid plexus: 20 nTPM
cerebral cortex: 18 nTPM
thalamus: 17 nTPM
hypothalamus: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.45
gnomAD pLI: 0.79
DepMap mean gene effect: -0.2
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Circadian-associated transcriptional repressor
Circadian-associated transcriptional repressor

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CIART in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CIART as an antibody target. Whether an autoantibody or antibody against CIART could matter depends on whether native CIART is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CIART is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CIART as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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