Seroatlas · Human Serome Atlas

CHMP4B

Charged multivesicular body protein 4b

Also known as: C20orf178, CHM4B_HUMAN, dJ553F4.4, Shax1, SNF7-2, VPS32B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H444
Gene
CHMP4B
Ensembl
ENSG00000101421
Chromosome
20
Canonical length
224 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of the chromatin-modifying protein/charged multivesicular body protein (CHMP) protein family. The protein is part of the endosomal sorting complex required for transport (ESCRT) complex III (ESCRT-III), which functions in the sorting of endocytosed cell-surface receptors into multivesicular endosomes. The ESCRT machinery also functions in the final abscisson stage of cytokinesis and in the budding of enveloped viruses such as HIV-1. The three proteins of the CHMP4 subfamily interact with programmed cell death 6 interacting protein (PDCD6IP, also known as ALIX), which also functions in the ESCRT pathway. The CHMP4 proteins assemble into membrane-attached 5-nm filaments that form circular scaffolds and promote or stabilize outward budding. These polymers are proposed to help generate the luminal vesicles of multivesicular bodies. Mutations in this gene result in autosomal dominant posterior polar cataracts.[provided by RefSeq, Oct 2009]

Canonical amino-acid sequenceUniProt

224 residues, UniProt reviewed canonical sequence.

>Q9H444|CHMP4B
     1  MSVFGKLFGA GGGKAGKGGP TPQEAIQRLR DTEEMLSKKQ EFLEKKIEQE LTAAKKHGTK
    61  NKRAALQALK RKKRYEKQLA QIDGTLSTIE FQREALENAN TNTEVLKNMG YAAKAMKAAH
   121  DNMDIDKVDE LMQDIADQQE LAEEISTAIS KPVGFGEEFD EDELMAELEE LEQEELDKNL
   181  LEISGPETVP LPNVPSIALP SKPAKKKEEE DDDMKELENW AGSM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CHMP4B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.51
Highest tissue expression
228 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 228 nTPM
  • bone marrow: 202 nTPM
  • blood vessel: 175 nTPM
  • cerebral cortex: 162 nTPM
  • esophagus: 157 nTPM
  • colon: 151 nTPM

Single-cell type

  • esophageal apical cells: 776 nCPM
  • syncytiotrophoblasts: 603 nCPM
  • esophageal suprabasal cells: 592 nCPM
  • enterocytes: 565 nCPM
  • colonocytes: 483 nCPM
  • neutrophils: 414 nCPM

Immune cell

  • plasmacytoid DC: 4 nTPM
  • neutrophil: 2.3 nTPM
  • classical monocyte: 1.8 nTPM
  • intermediate monocyte: 1.7 nTPM
  • memory B-cell: 1.6 nTPM
  • non-classical monocyte: 1.4 nTPM

Brain region

  • cerebral cortex: 108 nTPM
  • hypothalamus: 90 nTPM
  • medulla oblongata: 88 nTPM
  • white matter: 88 nTPM
  • thalamus: 86 nTPM
  • pons: 84 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CHMP4B.

Disease | AllUniProt

Conditions CHMP4B is implicated in, by any mechanism.

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 48 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Cataract 31 multiple types

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.3
gnomAD pLI
0.96
gnomAD missense Z
2.38
DepMap mean gene effect
-1.04
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 14% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CHMP4B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CHMP4B as an antibody target. Whether an autoantibody or antibody against CHMP4B could matter depends on whether native CHMP4B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CHMP4B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CHMP4B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CHMP4B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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