Seroatlas · Human Serome Atlas

CHMP1B

Charged multivesicular body protein 1b

Also known as: C18orf2, CHM1B_HUMAN, CHMP1.5, Vps46B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7LBR1
Gene
CHMP1B
Ensembl
ENSG00000255112
Chromosome
18
Canonical length
199 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Midbody

OverviewNCBI Gene

CHMP1B belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

199 residues, UniProt reviewed canonical sequence.

>Q7LBR1|CHMP1B
     1  MSNMEKHLFN LKFAAKELSR SAKKCDKEEK AEKAKIKKAI QKGNMEVARI HAENAIRQKN
    61  QAVNFLRMSA RVDAVAARVQ TAVTMGKVTK SMAGVVKSMD ATLKTMNLEK ISALMDKFEH
   121  QFETLDVQTQ QMEDTMSSTT TLTTPQNQVD MLLQEMADEA GLDLNMELPQ GQTGSVGTSV
   181  ASAEQDELSQ RLARLRDQV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CHMP1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
345 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 345 nTPM
  • blood vessel: 74 nTPM
  • bone marrow: 58 nTPM
  • tongue: 50 nTPM
  • thyroid gland: 49 nTPM
  • urinary bladder: 46 nTPM

Single-cell type

  • suprabasal keratinocytes: 3.9 nCPM
  • parietal cells: 3.5 nCPM
  • conjunctival goblet cells: 2.9 nCPM
  • cdc: 2.8 nCPM
  • enterocytes: 2.7 nCPM
  • ocular epithelial cells: 2.7 nCPM

Immune cell

  • neutrophil: 78 nTPM
  • eosinophil: 67 nTPM
  • classical monocyte: 39 nTPM
  • non-classical monocyte: 37 nTPM
  • intermediate monocyte: 36 nTPM
  • basophil: 33 nTPM

Brain region

  • choroid plexus: 56 nTPM
  • hypothalamus: 46 nTPM
  • hippocampal formation: 46 nTPM
  • basal ganglia: 46 nTPM
  • cerebral cortex: 45 nTPM
  • thalamus: 44 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.69
gnomAD pLI
0.73
gnomAD missense Z
0.26
DepMap mean gene effect
0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CHMP1B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CHMP1B as an antibody target. Whether an autoantibody or antibody against CHMP1B could matter depends on whether native CHMP1B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CHMP1B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CHMP1B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CHMP1B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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