Seroatlas · Human Serome Atlas

CHMP2A

Charged multivesicular body protein 2a

Also known as: BC-2, CHM2A_HUMAN, CHMP2, VPS2, VPS2A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O43633
Gene
CHMP2A
Ensembl
ENSG00000130724
Chromosome
19
Canonical length
222 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

CHMP2A belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

222 residues, UniProt reviewed canonical sequence.

>O43633|CHMP2A
     1  MDLLFGRRKT PEELLRQNQR ALNRAMRELD RERQKLETQE KKIIADIKKM AKQGQMDAVR
    61  IMAKDLVRTR RYVRKFVLMR ANIQAVSLKI QTLKSNNSMA QAMKGVTKAM GTMNRQLKLP
   121  QIQKIMMEFE RQAEIMDMKE EMMNDAIDDA MGDEEDEEES DAVVSQVLDE LGLSLTDELS
   181  NLPSTGGSLS VAAGGKKAEA AASALADADA DLEERLKNLR RD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CHMP2A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.47
Highest tissue expression
213 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 213 nTPM
  • adrenal gland: 176 nTPM
  • choroid plexus: 175 nTPM
  • heart muscle: 172 nTPM
  • basal ganglia: 164 nTPM
  • kidney: 164 nTPM

Single-cell type

  • esophageal apical cells: 1,199 nCPM
  • syncytiotrophoblasts: 612 nCPM
  • esophageal suprabasal cells: 602 nCPM
  • enterocytes: 550 nCPM
  • colonocytes: 496 nCPM
  • extravillous trophoblasts: 401 nCPM

Immune cell

  • neutrophil: 799 nTPM
  • eosinophil: 346 nTPM
  • basophil: 276 nTPM
  • classical monocyte: 245 nTPM
  • non-classical monocyte: 243 nTPM
  • intermediate monocyte: 231 nTPM

Brain region

  • white matter: 89 nTPM
  • medulla oblongata: 86 nTPM
  • cerebellum: 84 nTPM
  • cerebral cortex: 84 nTPM
  • spinal cord: 79 nTPM
  • thalamus: 78 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CHMP2A.

Disease | ImmuneIEDB

Conditions an epitope on CHMP2A was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.8
gnomAD pLI
0.13
gnomAD missense Z
0.9
DepMap mean gene effect
-1.84
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CHMP2A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CHMP2A as an antibody target. Whether an autoantibody or antibody against CHMP2A could matter depends on whether native CHMP2A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CHMP2A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CHMP2A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CHMP2A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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