Seroatlas · Human Serome Atlas

CHMP6

Charged multivesicular body protein 6

Also known as: CHMP6_HUMAN, FLJ11749, VPS20

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96FZ7
Gene: CHMP6
Ensembl: ENSG00000176108
Chromosome: 17
Canonical length: 201 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of the chromatin-modifying protein/charged multivesicular body protein family. Proteins in this family are part of the ESCRT-III (endosomal sorting complex required for transport III) which degrades surface receptors, and in biosynthesis of endosomes. [provided by RefSeq, Mar 2012]

Canonical amino-acid sequenceUniProt

201 residues, UniProt reviewed canonical sequence.

>Q96FZ7|CHMP6
     1  MGNLFGRKKQ SRVTEQDKAI LQLKQQRDKL RQYQKRIAQQ LERERALARQ LLRDGRKERA
    61  KLLLKKKRYQ EQLLDRTENQ ISSLEAMVQS IEFTQIEMKV MEGLQFGNEC LNKMHQVMSI
   121  EEVERILDET QEAVEYQRQI DELLAGSFTQ EDEDAILEEL SAITQEQIEL PEVPSEPLPE
   181  KIPENVPVKA RPRQAELVAA S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CHMP6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 43 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 43 nTPM
liver: 35 nTPM
tongue: 27 nTPM
spleen: 25 nTPM
esophagus: 24 nTPM
heart muscle: 23 nTPM

Single-cell type

platelets: 237 nCPM
megakaryocytes: 74 nCPM
syncytiotrophoblasts: 63 nCPM
esophageal apical cells: 62 nCPM
hofbauer cells: 59 nCPM
esophageal suprabasal cells: 55 nCPM

Immune cell

eosinophil: 84 nTPM
basophil: 67 nTPM
non-classical monocyte: 53 nTPM
NK-cell: 44 nTPM
intermediate monocyte: 43 nTPM
classical monocyte: 41 nTPM

Brain region

white matter: 29 nTPM
medulla oblongata: 29 nTPM
cerebral cortex: 26 nTPM
amygdala: 26 nTPM
pons: 26 nTPM
basal ganglia: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.24
gnomAD pLI: 0.98
gnomAD missense Z: 0.17
DepMap mean gene effect: -1.59
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

protein-containing complex binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CHMP6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CHMP6 as an antibody target. Whether an autoantibody or antibody against CHMP6 could matter depends on whether native CHMP6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CHMP6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CHMP6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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