Seroatlas · Human Serome Atlas

CHMP7

Charged multivesicular body protein 7

Also known as: CHMP7_HUMAN, MGC29816

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8WUX9
Gene
CHMP7
Ensembl
ENSG00000147457
Chromosome
8
Canonical length
453 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

Involved in several processes, including midbody abscission; mitotic nuclear division; and vacuolar transport. Located in several cellular components, including bounding membrane of organelle; chromosome; and nucleus. Part of ESCRT III complex and nuclear pore. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

453 residues, UniProt reviewed canonical sequence.

>Q8WUX9|CHMP7
     1  MWSPEREAEA PAGGDPAGLL PPEWEEDEER MSFLFSAFKR SREVNSTDWD SKMGFWAPLV
    61  LSHSRRQGVV RLRLRDLQEA FQRKGSVPLG LATVLQDLLR RGELQRESDF MASVDSSWIS
   121  WGVGVFLLKP LKWTLSNMLG DNKVPAEEVL VAVELLKEKA EEVYRLYQNS PLSSHPVVAL
   181  SELSTLCANS CPDERTFYLV LLQLQKEKRV TVLEQNGEKI VKFARGPRAK VSPVNDVDVG
   241  VYQLMQSEQL LSRKVESLSQ EAERCKEEAR RACRAGKKQL ALRSLKAKQR TEKRIEALHA
   301  KLDTVQGILD RIYASQTDQM VFNAYQAGVG ALKLSMKDVT VEKAESLVDQ IQELCDTQDE
   361  VSQTLAGGVT NGLDFDSEEL EKELDILLQD TTKEPLDLPD NPRNRHFTNS VPNPRISDAE
   421  LEAELEKLSL SEGGLVPSSK SPKRQLEPTL KPL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CHMP7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
31 nTPM

Expression across tissuesHPA

Tissue

  • lymph node: 31 nTPM
  • thymus: 29 nTPM
  • tonsil: 26 nTPM
  • appendix: 18 nTPM
  • spleen: 16 nTPM
  • small intestine: 13 nTPM

Single-cell type

  • b-cells: 49 nCPM
  • early spermatids: 41 nCPM
  • late primary spermatocytes: 38 nCPM
  • t-cells: 28 nCPM
  • syncytiotrophoblasts: 25 nCPM
  • extravillous trophoblasts: 24 nCPM

Immune cell

  • naive CD4 T-cell: 77 nTPM
  • T-reg: 47 nTPM
  • naive CD8 T-cell: 45 nTPM
  • memory CD4 T-cell: 41 nTPM
  • memory B-cell: 36 nTPM
  • naive B-cell: 36 nTPM

Brain region

  • white matter: 20 nTPM
  • medulla oblongata: 19 nTPM
  • pons: 19 nTPM
  • cerebellum: 19 nTPM
  • thalamus: 18 nTPM
  • hypothalamus: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.38
gnomAD pLI
0.86
gnomAD missense Z
1.5
DepMap mean gene effect
-0.56
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Snf7 family
  • Snf7
  • CHMP7, winged helix domain
  • Charged multivesicular body protein 7, winged helix domain
  • CHMP7 N-terminal winged helix domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CHMP7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CHMP7 as an antibody target. Whether an autoantibody or antibody against CHMP7 could matter depends on whether native CHMP7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CHMP7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CHMP7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CHMP7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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