Seroatlas · Human Serome Atlas

CHMP3

Charged multivesicular body protein 3

Also known as: CGI-149, CHMP3_HUMAN, NEDF, VPS24

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y3E7
Gene
CHMP3
Ensembl
ENSG00000115561
Chromosome
2
Canonical length
222 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a protein that sorts transmembrane proteins into lysosomes/vacuoles via the multivesicular body (MVB) pathway. This protein, along with other soluble coiled-coil containing proteins, forms part of the ESCRT-III protein complex that binds to the endosomal membrane and recruits additional cofactors for protein sorting into the MVB. This protein may also co-immunoprecipitate with a member of the IFG-binding protein superfamily. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ring finger protein 103 (RNF103) gene. [provided by RefSeq, Nov 2010]

Canonical amino-acid sequenceUniProt

222 residues, UniProt reviewed canonical sequence.

>Q9Y3E7|CHMP3
     1  MGLFGKTQEK PPKELVNEWS LKIRKEMRVV DRQIRDIQRE EEKVKRSVKD AAKKGQKDVC
    61  IVLAKEMIRS RKAVSKLYAS KAHMNSVLMG MKNQLAVLRV AGSLQKSTEV MKAMQSLVKI
   121  PEIQATMREL SKEMMKAGII EEMLEDTFES MDDQEEMEEE AEMEIDRILF EITAGALGKA
   181  PSKVTDALPE PEPPGAMAAS EDEEEEEEAL EAMQSRLATL RS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CHMP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
94 nTPM

Expression across tissuesHPA

Tissue

  • heart muscle: 94 nTPM
  • skeletal muscle: 91 nTPM
  • esophagus: 87 nTPM
  • blood vessel: 80 nTPM
  • tongue: 76 nTPM
  • basal ganglia: 71 nTPM

Single-cell type

  • esophageal apical cells: 444 nCPM
  • esophageal suprabasal cells: 206 nCPM
  • parietal cells: 195 nCPM
  • late primary spermatocytes: 184 nCPM
  • platelets: 183 nCPM
  • colonocytes: 176 nCPM

Immune cell

  • neutrophil: 229 nTPM
  • eosinophil: 172 nTPM
  • basophil: 159 nTPM
  • intermediate monocyte: 74 nTPM
  • non-classical monocyte: 67 nTPM
  • classical monocyte: 62 nTPM

Brain region

  • basal ganglia: 92 nTPM
  • cerebellum: 82 nTPM
  • cerebral cortex: 75 nTPM
  • thalamus: 70 nTPM
  • hypothalamus: 64 nTPM
  • amygdala: 63 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.89
gnomAD pLI
0
gnomAD missense Z
0.8
DepMap mean gene effect
-0.82
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CHMP3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CHMP3 as an antibody target. Whether an autoantibody or antibody against CHMP3 could matter depends on whether native CHMP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CHMP3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CHMP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CHMP3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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