Seroatlas · Human Serome Atlas

CHMP4A

Charged multivesicular body protein 4a

Also known as: C14orf123, CHM4A_HUMAN, HSPC134, VPS32A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BY43
Gene
CHMP4A
Ensembl
ENSG00000254505
Chromosome
14
Canonical length
222 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

CHMP4A belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

222 residues, UniProt reviewed canonical sequence.

>Q9BY43|CHMP4A
     1  MSGLGRLFGK GKKEKGPTPE EAIQKLKETE KILIKKQEFL EQKIQQELQT AKKYGTKNKR
    61  AALQALRRKK RFEQQLAQTD GTLSTLEFQR EAIENATTNA EVLRTMELAA QSMKKAYQDM
   121  DIDKVDELMT DITEQQEVAQ QISDAISRPM GFGDDVDEDE LLEELEELEQ EELAQELLNV
   181  GDKEEEPSVK LPSVPSTHLP AGPAPKVDED EEALKQLAEW VS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CHMP4A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
110 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 110 nTPM
  • midbrain: 98 nTPM
  • spinal cord: 92 nTPM
  • amygdala: 89 nTPM
  • colon: 85 nTPM
  • basal ganglia: 81 nTPM

Single-cell type

  • microglia: 20 nCPM
  • oligodendrocytes: 17 nCPM
  • astrocytes: 12 nCPM
  • brain excitatory neurons: 12 nCPM
  • bergmann glia: 11 nCPM
  • other brain neurons: 11 nCPM

Immune cell

  • intermediate monocyte: 196 nTPM
  • non-classical monocyte: 195 nTPM
  • plasmacytoid DC: 190 nTPM
  • T-reg: 186 nTPM
  • memory B-cell: 184 nTPM
  • myeloid DC: 180 nTPM

Brain region

  • thalamus: 39 nTPM
  • basal ganglia: 36 nTPM
  • medulla oblongata: 36 nTPM
  • spinal cord: 36 nTPM
  • white matter: 36 nTPM
  • pons: 33 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.58
gnomAD pLI
0
gnomAD missense Z
0.7
DepMap mean gene effect
-0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CHMP4A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CHMP4A as an antibody target. Whether an autoantibody or antibody against CHMP4A could matter depends on whether native CHMP4A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CHMP4A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CHMP4A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CHMP4A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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