Seroatlas · Human Serome Atlas

CHMP5

Charged multivesicular body protein 5

Also known as: C9orf83, CGI-34, CHMP5_HUMAN, HSPC177, SNF7DC2, Vps60

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NZZ3
Gene
CHMP5
Ensembl
ENSG00000086065
Chromosome
9
Canonical length
219 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Microtubules,Midbody,Cytosol

OverviewNCBI Gene

CHMP5 belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

219 residues, UniProt reviewed canonical sequence.

>Q9NZZ3|CHMP5
     1  MNRLFGKAKP KAPPPSLTDC IGTVDSRAES IDKKISRLDA ELVKYKDQIK KMREGPAKNM
    61  VKQKALRVLK QKRMYEQQRD NLAQQSFNME QANYTIQSLK DTKTTVDAMK LGVKEMKKAY
   121  KQVKIDQIED LQDQLEDMME DANEIQEALS RSYGTPELDE DDLEAELDAL GDELLADEDS
   181  SYLDEAASAP AIPEGVPTDT KNKDGVLVDE FGLPQIPAS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CHMP5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
73 nTPM

Expression across tissuesHPA

Tissue

  • kidney: 73 nTPM
  • parathyroid gland: 60 nTPM
  • placenta: 60 nTPM
  • spinal cord: 58 nTPM
  • choroid plexus: 57 nTPM
  • cerebral cortex: 56 nTPM

Single-cell type

  • esophageal apical cells: 1,078 nCPM
  • early spermatids: 372 nCPM
  • syncytiotrophoblasts: 321 nCPM
  • parietal cells: 290 nCPM
  • gastric progenitor cells: 254 nCPM
  • extravillous trophoblasts: 251 nCPM

Immune cell

  • neutrophil: 130 nTPM
  • eosinophil: 107 nTPM
  • basophil: 99 nTPM
  • plasmacytoid DC: 71 nTPM
  • non-classical monocyte: 68 nTPM
  • intermediate monocyte: 57 nTPM

Brain region

  • white matter: 47 nTPM
  • spinal cord: 40 nTPM
  • medulla oblongata: 35 nTPM
  • hypothalamus: 35 nTPM
  • cerebral cortex: 35 nTPM
  • cerebellum: 34 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.81
gnomAD pLI
0.01
gnomAD missense Z
0.73
DepMap mean gene effect
-0.48
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CHMP5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CHMP5 as an antibody target. Whether an autoantibody or antibody against CHMP5 could matter depends on whether native CHMP5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CHMP5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CHMP5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CHMP5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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