Seroatlas · Human Serome Atlas

CHMP2B

Charged multivesicular body protein 2b

Also known as: CHM2B_HUMAN, CHMP2.5, DKFZP564O123, VPS2B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UQN3
Gene
CHMP2B
Ensembl
ENSG00000083937
Chromosome
3
Canonical length
213 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

This gene encodes a component of the heteromeric ESCRT-III complex (Endosomal Sorting Complex Required for Transport III) that functions in the recycling or degradation of cell surface receptors. ESCRT-III functions in the concentration and invagination of ubiquitinated endosomal cargos into intralumenal vesicles. The protein encoded by this gene is found as a monomer in the cytosol or as an oligomer in ESCRT-III complexes on endosomal membranes. It is expressed in neurons of all major regions of the brain. Mutations in this gene result in one form of familial frontotemporal lobar degeneration. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

213 residues, UniProt reviewed canonical sequence.

>Q9UQN3|CHMP2B
     1  MASLFKKKTV DDVIKEQNRE LRGTQRAIIR DRAALEKQEK QLELEIKKMA KIGNKEACKV
    61  LAKQLVHLRK QKTRTFAVSS KVTSMSTQTK VMNSQMKMAG AMSTTAKTMQ AVNKKMDPQK
   121  TLQTMQNFQK ENMKMEMTEE MINDTLDDIF DGSDDEEESQ DIVNQVLDEI GIEISGKMAK
   181  APSAARSLPS ASTSKATISD EEIERQLKAL GVD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CHMP2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
51 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 51 nTPM
  • thyroid gland: 40 nTPM
  • bone marrow: 40 nTPM
  • urinary bladder: 40 nTPM
  • colon: 39 nTPM
  • small intestine: 38 nTPM

Single-cell type

  • esophageal apical cells: 649 nCPM
  • extravillous trophoblasts: 262 nCPM
  • syncytiotrophoblasts: 237 nCPM
  • neutrophils: 220 nCPM
  • colonocytes: 213 nCPM
  • urothelial cells: 203 nCPM

Immune cell

  • eosinophil: 137 nTPM
  • basophil: 125 nTPM
  • neutrophil: 97 nTPM
  • non-classical monocyte: 68 nTPM
  • intermediate monocyte: 65 nTPM
  • myeloid DC: 55 nTPM

Brain region

  • white matter: 54 nTPM
  • medulla oblongata: 42 nTPM
  • spinal cord: 37 nTPM
  • cerebellum: 34 nTPM
  • pons: 33 nTPM
  • midbrain: 32 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CHMP2B.

Disease | AllUniProt

Conditions CHMP2B is implicated in, by any mechanism.

  • Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 (FTDALS7) MIM:600795

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 195 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Frontotemporal dementia and/or amyotrophic lateral sclerosis 7
  • Cervical cancer

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.22
gnomAD pLI
0
gnomAD missense Z
0.34
DepMap mean gene effect
-0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CHMP2B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CHMP2B as an antibody target. Whether an autoantibody or antibody against CHMP2B could matter depends on whether native CHMP2B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CHMP2B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CHMP2B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CHMP2B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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