Seroatlas · Human Serome Atlas

CHMP4C

Charged multivesicular body protein 4c

Also known as: CHM4C_HUMAN, MGC22825, Shax3, VPS32C

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96CF2
Gene
CHMP4C
Ensembl
ENSG00000164695
Chromosome
8
Canonical length
233 aa
Protein class
Predicted intracellular proteins
Subcellular location
Microtubules,Cytokinetic bridge

OverviewNCBI Gene

CHMP4C belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

233 residues, UniProt reviewed canonical sequence.

>Q96CF2|CHMP4C
     1  MSKLGKFFKG GGSSKSRAAP SPQEALVRLR ETEEMLGKKQ EYLENRIQRE IALAKKHGTQ
    61  NKRAALQALK RKKRFEKQLT QIDGTLSTIE FQREALENSH TNTEVLRNMG FAAKAMKSVH
   121  ENMDLNKIDD LMQEITEQQD IAQEISEAFS QRVGFGDDFD EDELMAELEE LEQEELNKKM
   181  TNIRLPNVPS SSLPAQPNRK PGMSSTARRS RAASSQRAEE EDDDIKQLAA WAT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CHMP4C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.51
Highest tissue expression
39 nTPM

Expression across tissuesHPA

Tissue

  • duodenum: 39 nTPM
  • small intestine: 30 nTPM
  • skin: 28 nTPM
  • salivary gland: 26 nTPM
  • stomach: 22 nTPM
  • esophagus: 22 nTPM

Single-cell type

  • esophageal apical cells: 309 nCPM
  • enterocytes: 86 nCPM
  • esophageal suprabasal cells: 68 nCPM
  • urothelial cells: 58 nCPM
  • extravillous trophoblasts: 56 nCPM
  • pancreatic acinar cells: 56 nCPM

Immune cell

  • NK-cell: 1.9 nTPM
  • basophil: 0.3 nTPM
  • memory B-cell: 0.3 nTPM
  • neutrophil: 0.3 nTPM
  • classical monocyte: 0.1 nTPM
  • naive B-cell: 0.1 nTPM

Brain region

  • choroid plexus: 5.4 nTPM
  • midbrain: 2 nTPM
  • white matter: 1.9 nTPM
  • pons: 1.8 nTPM
  • medulla oblongata: 1.7 nTPM
  • thalamus: 1.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.41
gnomAD pLI
0
gnomAD missense Z
-0.15
DepMap mean gene effect
-0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CHMP4C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CHMP4C as an antibody target. Whether an autoantibody or antibody against CHMP4C could matter depends on whether native CHMP4C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CHMP4C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CHMP4C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CHMP4C. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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