Seroatlas · Human Serome Atlas

ENKD1

Enkurin domain-containing protein 1

Also known as: C16orf48, DKFZP434A1319, ENKD1_HUMAN, FBB11

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H0I2
Gene: ENKD1
Ensembl: ENSG00000124074
Chromosome: 16
Canonical length: 346 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane,Primary cilium,Centrosome,Basal body

OverviewNCBI Gene

Enables alpha-tubulin binding activity and microtubule binding activity. Involved in establishment of mitotic spindle orientation and non-motile cilium assembly. Located in microtubule cytoskeleton and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

346 residues, UniProt reviewed canonical sequence.

>Q9H0I2|ENKD1
     1  MCEGPSRISG PIPPDPTLCP DNYRRPTSAQ GRLEGNALKL DLLTSDRALD TTAPRGPCIG
    61  PGAGEILERG QRGVGDVLLQ LEGISLGPGA SLKRKDPKDH EKENLRRIRE IQKRFREQER
   121  SREQGQPRPL KALWRSPKYD KVESRVKAQL QEPGPASGTE SAHFLRAHSR CGPGLPPPHV
   181  SSPQPTPPGP EAKEPGLGVD FIRHNARAAK RAPRRHSCSL QVLAQVLEQQ RQAQEHYNAT
   241  QKGHVPHYLL ERRDLWRREA EARKQSQPDP AMPPGHTRMP ENQRLETLTK LLQSQSQLLR
   301  ELVLLPAGAD SLRAQSHRAE LDRKLVQVEE AIKIFSRPKV FVKMDD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ENKD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 65 nTPM

Expression across tissuesHPA

Tissue

pancreas: 65 nTPM
testis: 40 nTPM
fallopian tube: 30 nTPM
kidney: 29 nTPM
colon: 28 nTPM
pituitary gland: 25 nTPM

Single-cell type

respiratory ciliated cells: 82 nCPM
fallopian tube ciliated cells: 75 nCPM
epididymal efferent duct ciliated cells: 50 nCPM
endometrial ciliated cells: 43 nCPM
early spermatids: 40 nCPM
early primary spermatocytes: 33 nCPM

Immune cell

plasmacytoid DC: 1.3 nTPM
neutrophil: 0.9 nTPM
classical monocyte: 0.4 nTPM
MAIT T-cell: 0.4 nTPM
memory CD4 T-cell: 0.3 nTPM
naive CD8 T-cell: 0.3 nTPM

Brain region

cerebellum: 38 nTPM
choroid plexus: 20 nTPM
midbrain: 15 nTPM
spinal cord: 13 nTPM
medulla oblongata: 13 nTPM
thalamus: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.34
gnomAD pLI: 0
gnomAD missense Z: -0.23
DepMap mean gene effect: -0.19
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ENKD1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ENKD1 as an antibody target. Whether an autoantibody or antibody against ENKD1 could matter depends on whether native ENKD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ENKD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ENKD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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