Seroatlas · Human Serome Atlas

CDCA7L

Cell division cycle-associated 7-like protein

Also known as: CDA7L_HUMAN, JPO2, R1, RAM2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96GN5
Gene
CDCA7L
Ensembl
ENSG00000164649
Chromosome
7
Canonical length
454 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli,Nucleoli fibrillar center,Cytosol

OverviewNCBI Gene

Acts upstream of or within positive regulation of cell population proliferation. Located in cytosol; fibrillar center; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

454 residues, UniProt reviewed canonical sequence.

>Q96GN5|CDCA7L
     1  MELATRYQIP KEVADIFNAP SDDEEFVGFR DDVPMETLSS EESCDSFDSL ESGKQQDVRF
    61  HSKYFTEELR RIFIEDTDSE TEDFAGFTQS DLNGKTNPEV MVVESDLSDD GKASLVSEEE
   121  EDEEEDKATP RRSRSRRSSI GLRVAFQFPT KKLANKPDKN SSSEQLFSSA RLQNEKKTIL
   181  ERKKDCRQVI QREDSTSESE DDSRDESQES SDALLKRTMN IKENKAMLAQ LLAELNSMPD
   241  FFPVRTPTSA SRKKTVRRAF SEGQITRRMN PTRSARPPEK FALENFTVSA AKFAEEFYSF
   301  RRRKTIGGKC REYRRRHRIS SFRPVEDITE EDLENVAITV RDKIYDKVLG NTCHQCRQKT
   361  IDTKTVCRNQ GCCGVRGQFC GPCLRNRYGE DVRSALLDPD WVCPPCRGIC NCSYCRKRDG
   421  RCATGILIHL AKFYGYDNVK EYLESLQKEL VEDN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDCA7L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.57
Highest tissue expression
49 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 49 nTPM
  • thymus: 46 nTPM
  • lymph node: 35 nTPM
  • tonsil: 30 nTPM
  • thyroid gland: 28 nTPM
  • heart muscle: 24 nTPM

Single-cell type

  • oocytes: 263 nCPM
  • neutrophil progenitors: 181 nCPM
  • undifferentiated spermatogonia: 82 nCPM
  • differentiating spermatogonia: 61 nCPM
  • cardiomyocytes: 60 nCPM
  • b-cells: 54 nCPM

Immune cell

  • naive B-cell: 125 nTPM
  • memory B-cell: 101 nTPM
  • plasmacytoid DC: 76 nTPM
  • eosinophil: 43 nTPM
  • naive CD4 T-cell: 31 nTPM
  • myeloid DC: 15 nTPM

Brain region

  • choroid plexus: 38 nTPM
  • white matter: 20 nTPM
  • basal ganglia: 19 nTPM
  • thalamus: 17 nTPM
  • medulla oblongata: 16 nTPM
  • cerebellum: 12 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CDCA7L.

Disease | ImmuneIEDB

Conditions an epitope on CDCA7L was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.68
gnomAD pLI
0
gnomAD missense Z
-0.09
DepMap mean gene effect
0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CDCA7L in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDCA7L as an antibody target. Whether an autoantibody or antibody against CDCA7L could matter depends on whether native CDCA7L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDCA7L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CDCA7L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CDCA7L. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...