Seroatlas · Human Serome Atlas

TAF1D

TATA box-binding protein-associated factor RNA polymerase I subunit D

Also known as: JOSD3, MGC5306, TAF(I)41, TAF1D_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H5J8
Gene
TAF1D
Ensembl
ENSG00000166012
Chromosome
11
Canonical length
278 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm,Nucleoli,Mitotic spindle,Centriolar satellite

OverviewNCBI Gene

TAF1D is a member of the SL1 complex, which includes TBP (MIM 600075) and TAF1A (MIM 604903), TAF1B (MIM 604904), and TAF1C (MIM 604905), and plays a role in RNA polymerase I transcription (Wang et al., 2004 [PubMed 15520167]; Gorski et al., 2007 [PubMed 17318177]).[supplied by OMIM, Jun 2009]

Canonical amino-acid sequenceUniProt

278 residues, UniProt reviewed canonical sequence.

>Q9H5J8|TAF1D
     1  MDKSGIDSLD HVTSDAVELA NRSDNSSDSS LFKTQCIPYS PKGEKRNPIR KFVRTPESVH
    61  ASDSSSDSSF EPIPLTIKAI FERFKNRKKR YKKKKKRRYQ PTGRPRGRPE GRRNPIYSLI
   121  DKKKQFRSRG SGFPFLESEN EKNAPWRKIL TFEQAVARGF FNYIEKLKYE HHLKESLKQM
   181  NVGEDLENED FDSRRYKFLD DDGSISPIEE STAEDEDATH LEDNECDIKL AGDSFIVSSE
   241  FPVRLSVYLE EEDITEEAAL SKKRATKAKN TGQRGLKM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TAF1D can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.66
Highest tissue expression
22 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 22 nTPM
  • lymph node: 19 nTPM
  • appendix: 17 nTPM
  • ovary: 17 nTPM
  • placenta: 17 nTPM
  • skeletal muscle: 17 nTPM

Single-cell type

  • cardiomyocytes: 549 nCPM
  • pancreatic acinar cells: 415 nCPM
  • megakaryocyte-erythroid progenitors: 355 nCPM
  • migrating cytotrophoblasts: 285 nCPM
  • endometrial glandular cells: 281 nCPM
  • basal keratinocytes: 272 nCPM

Immune cell

  • basophil: 44 nTPM
  • neutrophil: 43 nTPM
  • naive B-cell: 40 nTPM
  • memory B-cell: 39 nTPM
  • eosinophil: 29 nTPM
  • naive CD4 T-cell: 29 nTPM

Brain region

  • white matter: 38 nTPM
  • cerebral cortex: 36 nTPM
  • cerebellum: 33 nTPM
  • hypothalamus: 30 nTPM
  • pons: 28 nTPM
  • medulla oblongata: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.35
gnomAD pLI
0
gnomAD missense Z
0.37
DepMap mean gene effect
-0.69
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • TATA box-binding protein-associated factor 1D
  • TATA box-binding protein-associated factor 1D

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TAF1D in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TAF1D as an antibody target. Whether an autoantibody or antibody against TAF1D could matter depends on whether native TAF1D is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TAF1D is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TAF1D as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TAF1D. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...