Seroatlas · Human Serome Atlas

ZNF136

Zinc finger protein 136

Also known as: pHZ-20, ZN136_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P52737
Gene
ZNF136
Ensembl
ENSG00000196646
Chromosome
19
Canonical length
540 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoli

OverviewNCBI Gene

This gene encodes a zinc finger protein containing a Kruppel-associated box (KRAB) A-box domain at its N-terminus, followed by fourteen contiguous C2H2 zinc finger domains and a degenerate zinc finger. The KRAB A-box showed weak transcriptional repressor activity in a reporter gene assay. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]

Canonical amino-acid sequenceUniProt

540 residues, UniProt reviewed canonical sequence.

>P52737|ZNF136
     1  MDSVAFEDVD VNFTQEEWAL LDPSQKNLYR DVMWETMRNL ASIGKKWKDQ NIKDHYKHRG
    61  RNLRSHMLER LYQTKDGSQR GGIFSQFANQ NLSKKIPGVK LCESIVYGEV SMGQSSLNRH
   121  IKDHSGHEPK EYQEYGEKPD TRNQCWKPFS SHHSFRTHEI IHTGEKLYDC KECGKTFFSL
   181  KRIRRHIITH SGYTPYKCKV CGKAFDYPSR FRTHERSHTG EKPYECQECG KAFTCITSVR
   241  RHMIKHTGDG PYKCKVCGKP FHSLSSFQVH ERIHTGEKPF KCKQCGKAFS CSPTLRIHER
   301  THTGEKPYEC KQCGKAFSYL PSLRLHERIH TGEKPFVCKQ CGKAFRSAST FQIHERTHTG
   361  EKPYECKECG EAFSCIPSMR RHMIKHTGEG PYKCKVCGKP FHSLSPFRIH ERTHTGEKPY
   421  VCKHCGKAFV SSTSIRIHER THTGEKPYEC KQCGKAFSYL NSFRTHEMIH TGEKPFECKR
   481  CGKAFRSSSS FRLHERTHTG QKPYHCKECG KAYSCRASFQ RHMLTHAEDG PPYKCMWESL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF136 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
15 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 15 nTPM
  • ovary: 10 nTPM
  • thyroid gland: 8.4 nTPM
  • endometrium: 7.8 nTPM
  • spleen: 7.5 nTPM
  • thymus: 7.3 nTPM

Single-cell type

  • early primary spermatocytes: 42 nCPM
  • b-cells: 34 nCPM
  • differentiating spermatogonia: 33 nCPM
  • nk-cells: 30 nCPM
  • erythrocyte progenitors: 26 nCPM
  • mast cells: 26 nCPM

Immune cell

  • basophil: 15 nTPM
  • neutrophil: 9.3 nTPM
  • NK-cell: 8.2 nTPM
  • naive B-cell: 8.1 nTPM
  • naive CD4 T-cell: 8.1 nTPM
  • MAIT T-cell: 8 nTPM

Brain region

  • cerebellum: 19 nTPM
  • white matter: 15 nTPM
  • pons: 13 nTPM
  • medulla oblongata: 13 nTPM
  • hypothalamus: 12 nTPM
  • thalamus: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.38
gnomAD pLI
0
gnomAD missense Z
1.28
DepMap mean gene effect
0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF136 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF136 as an antibody target. Whether an autoantibody or antibody against ZNF136 could matter depends on whether native ZNF136 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF136 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF136 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF136. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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