Seroatlas · Human Serome Atlas

METTL17

Ribosome assembly protein METTL17, mitochondrial

Also known as: FLJ20859, MET17_HUMAN, METT11D1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H7H0
Gene: METTL17
Ensembl: ENSG00000165792
Chromosome: 14
Canonical length: 456 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables 4 iron, 4 sulfur cluster binding activity. Involved in mitochondrial small ribosomal subunit assembly. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

456 residues, UniProt reviewed canonical sequence.

>Q9H7H0|METTL17
     1  MAAALKCLLT LGRWCPGLGV APQARALAAL VPGVTQVDNK SGFLQKRPHR QHPGILKLPH
    61  VRLPQALANG AQLLLLGSAG PTMENQVQTL TSYLWSRHLP VEPEELQRRA RHLEKKFLEN
   121  PDLSQTEEKL RGAVLHALRK TTYHWQELSY TEGLSLVYMA ARLDGGFAAV SRAFHEIRAR
   181  NPAFQPQTLM DFGSGTGSVT WAAHSIWGQS LREYMCVDRS AAMLVLAEKL LKGGSESGEP
   241  YIPGVFFRQF LPVSPKVQFD VVVSAFSLSE LPSKADRTEV VQTLWRKTGH FLVLVENGTK
   301  AGHSLLMDAR DLVLKGKEKS PLDPRPGFVF APCPHELPCP QLTNLACSFS QAYHPIPFSW
   361  NKKPKEEKFS MVILARGSPE EAHRWPRITQ PVLKRPRHVH CHLCCPDGHM QHAVLTARRH
   421  GRDLYRCARV SSWGDLLPVL TPSAFPPSTA QDPSES

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against METTL17 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 34 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 34 nTPM
tongue: 27 nTPM
heart muscle: 26 nTPM
skeletal muscle: 26 nTPM
bone marrow: 25 nTPM
spleen: 23 nTPM

Single-cell type

ocular epithelial cells: 108 nCPM
adrenal cortex cells: 107 nCPM
early spermatids: 49 nCPM
tuft cells: 46 nCPM
leydig cells: 45 nCPM
esophageal basal cells: 44 nCPM

Immune cell

basophil: 29 nTPM
myeloid DC: 17 nTPM
memory B-cell: 14 nTPM
memory CD8 T-cell: 13 nTPM
memory CD4 T-cell: 13 nTPM
naive CD4 T-cell: 12 nTPM

Brain region

choroid plexus: 13 nTPM
cerebral cortex: 12 nTPM
cerebellum: 11 nTPM
white matter: 11 nTPM
medulla oblongata: 10 nTPM
thalamus: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.06
gnomAD pLI: 0
gnomAD missense Z: 0.52
DepMap mean gene effect: -0.51
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

S-adenosyl-L-methionine-dependent methyltransferase superfamily
Ribosomal protein Rsm22-like
Mitochondrial RNA Methyltransferase
Mitochondrial small ribosomal subunit Rsm22

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of METTL17 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads METTL17 as an antibody target. Whether an autoantibody or antibody against METTL17 could matter depends on whether native METTL17 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

METTL17 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label METTL17 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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