Seroatlas · Human Serome Atlas

SUV39H2

Histone-lysine N-methyltransferase SUV39H2

Also known as: FLJ23414, KMT1B, SUV92_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H5I1
Gene
SUV39H2
Ensembl
ENSG00000152455
Chromosome
10
Canonical length
410 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Mitochondria

OverviewNCBI Gene

Enables cation binding activity; histone H3K9 methyltransferase activity; and ubiquitin-like ligase-substrate adaptor activity. Involved in epigenetic programming in the zygotic pronuclei. Acts upstream of or within cellular response to hypoxia and negative regulation of transcription by RNA polymerase II. Located in chromatin. Is active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

410 residues, UniProt reviewed canonical sequence.

>Q9H5I1|SUV39H2
     1  MAAVGAEARG AWCVPCLVSL DTLQELCRKE KLTCKSIGIT KRNLNNYEVE YLCDYKVVKD
    61  MEYYLVKWKG WPDSTNTWEP LQNLKCPLLL QQFSNDKHNY LSQVKKGKAI TPKDNNKTLK
   121  PAIAEYIVKK AKQRIALQRW QDELNRRKNH KGMIFVENTV DLEGPPSDFY YINEYKPAPG
   181  ISLVNEATFG CSCTDCFFQK CCPAEAGVLL AYNKNQQIKI PPGTPIYECN SRCQCGPDCP
   241  NRIVQKGTQY SLCIFRTSNG RGWGVKTLVK IKRMSFVMEY VGEVITSEEA ERRGQFYDNK
   301  GITYLFDLDY ESDEFTVDAA RYGNVSHFVN HSCDPNLQVF NVFIDNLDTR LPRIALFSTR
   361  TINAGEELTF DYQMKGSGDI SSDSIDHSPA KKRVRTVCKC GAVTCRGYLN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SUV39H2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
37 nTPM

Expression across tissuesHPA

Tissue

  • testis: 37 nTPM
  • thymus: 5.6 nTPM
  • bone marrow: 4.7 nTPM
  • breast: 3.6 nTPM
  • placenta: 3.6 nTPM
  • ovary: 3.2 nTPM

Single-cell type

  • early spermatids: 477 nCPM
  • late primary spermatocytes: 284 nCPM
  • late spermatids: 132 nCPM
  • differentiating spermatogonia: 60 nCPM
  • early primary spermatocytes: 55 nCPM
  • extravillous trophoblasts: 46 nCPM

Immune cell

  • NK-cell: 3.1 nTPM
  • T-reg: 2.1 nTPM
  • MAIT T-cell: 1.9 nTPM
  • memory CD8 T-cell: 1.8 nTPM
  • naive CD4 T-cell: 1.8 nTPM
  • naive CD8 T-cell: 1.8 nTPM

Brain region

  • cerebellum: 20 nTPM
  • cerebral cortex: 9.9 nTPM
  • white matter: 8.9 nTPM
  • basal ganglia: 6.1 nTPM
  • midbrain: 5.4 nTPM
  • amygdala: 5.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.36
gnomAD pLI
0.93
gnomAD missense Z
3.28
DepMap mean gene effect
0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SUV39H2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SUV39H2 as an antibody target. Whether an autoantibody or antibody against SUV39H2 could matter depends on whether native SUV39H2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SUV39H2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SUV39H2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SUV39H2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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