Seroatlas · Human Serome Atlas

FHDC1

FH2 domain-containing protein 1

Also known as: FHDC1_HUMAN, INF1, KIAA1727

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9C0D6
Gene: FHDC1
Ensembl: ENSG00000137460
Chromosome: 4
Canonical length: 1143 aa
Protein class: Predicted intracellular proteins
Subcellular location: Primary cilium,Centrosome,Basal body

OverviewNCBI Gene

Predicted to enable actin binding activity and microtubule binding activity. Involved in Golgi ribbon formation; cilium assembly; and stress fiber assembly. Located in cilium and microtubule. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1143 residues, UniProt reviewed canonical sequence.

>Q9C0D6|FHDC1
     1  MHVMNCVSLV SDKENGNIAT APGFMIGQTP PPAPPPPPPP PPPSPPCSCS REECPSSPPP
    61  PPPPPLPGEP PIPPPPPGLP PTTHMNGYSH LGKKKRMRSF FWKTIPEEQV RGKTNIWTLA
   121  ARQEHHYQID TKTIEELFGQ QEDTTKSSLP RRGRTLNSSF REAREEITIL DAKRSMNIGI
   181  FLKQFKKSPR SIVEDIHQGK SEHYGSETLR EFLKFLPESE EVKKLKAFSG DVSKLSLADS
   241  FLYGLIQVPN YSLRIEAMVL KKEFLPSCSS LYTDITVLRT AIKELMSCEE LHSILHLVLQ
   301  AGNIMNAGGY AGNAVGFKLS SLLKLADTKA NKPGMNLLHF VAQEAQKKDT ILLNFSEKLH
   361  HVQKTARLSL ENTEAELHLL FVRTKSLKEN IQRDGELCQQ MEDFLQFAIE KLRELECWKQ
   421  ELQDEAYTLI DFFCEDKKTM KLDECFQIFR DFCTKFNKAV KDNHDREAQE LRQLQRLKEQ
   481  EQKQRSWATG ELGAFGRSSS ENDVELLTKK GAEGLLPFLH PRPISPSSPS YRPPNTRRSR
   541  LSLGPSADRE LLTFLESSTG SPEEPNKFHS LPRSSPRQAR PTIACLEPAE VRHQDSSFAH
   601  KPQASGGQEE APNPPSAQAH QLAAAQPENH ASAFPRARRQ GVSVLRKRYS EPVSLGSAQS
   661  PPLSPLALGI KEHELVTGLA QFNLQGSQGM EETSQLTLSD FSPMELESVG HRGPQSLSAS
   721  SSSLTPMGRD ALGSLSPALE DGKAAPDEPG SAALGSVGSS DPENKDPRPL FCISDTTDCS
   781  LTLDCSEGTD SRPRGGDPEE GGEGDGSMSS GVGEMGDSQV SSNPTSSPPG EAPAPVSVDS
   841  EPSCKGGLPR DKPTKRKDVV APKRGSLKEA SPGASKPGSA RRSQGAVAKS VRTLTASENE
   901  SMRKVMPITK SSRGAGWRRP ELSSRGPSQN PPSSTDTVWS RQNSVRRAST GAEEQRLPRG
   961  SSGSSSTRPG RDVPLQPRGS FKKPSAKPLR NLPRQKPEEN KTCRAHSEGP ESPKEEPKTP
  1021  SVPSVPHELP RVPSFARNTV ASSSRSMRTD LPPVAKAPGI TRTVSQRQLR VKGDPEDAAP
  1081  KDSSTLRRAS SARAPKKRPE SAEGPSANTE APLKARGAGE RASLRRKDSS RTTLGRILNP
  1141  LRK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FHDC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 17 nTPM
thyroid gland: 15 nTPM
bone marrow: 14 nTPM
skin: 11 nTPM
lung: 8.1 nTPM
esophagus: 6.7 nTPM

Single-cell type

syncytiotrophoblasts: 196 nCPM
alveolar cells type 2: 111 nCPM
prostatic glandular cells: 55 nCPM
erythrocytes: 43 nCPM
transitional alveolar cells: 41 nCPM
esophageal apical cells: 40 nCPM

Immune cell

neutrophil: 0.3 nTPM
basophil: 0.1 nTPM
NK-cell: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

basal ganglia: 9.6 nTPM
thalamus: 7.8 nTPM
pons: 6.9 nTPM
cerebral cortex: 6.3 nTPM
cerebellum: 6.1 nTPM
medulla oblongata: 5.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.59
gnomAD pLI: 0
gnomAD missense Z: 0.11
DepMap mean gene effect: 0.11
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FHDC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CEP170

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FHDC1 as an antibody target. Whether an autoantibody or antibody against FHDC1 could matter depends on whether native FHDC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FHDC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FHDC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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