Seroatlas · Human Serome Atlas

CCDC68

Coiled-coil domain-containing protein 68

Also known as: CCD68_HUMAN, SE57-1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H2F9
Gene
CCDC68
Ensembl
ENSG00000166510
Chromosome
18
Canonical length
335 aa
Protein class
Predicted intracellular proteins
Subcellular location
Golgi apparatus,Cytosol

OverviewNCBI Gene

Involved in microtubule anchoring at centrosome and protein localization. Located in centriole. Part of centriolar subdistal appendage. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

335 residues, UniProt reviewed canonical sequence.

>Q9H2F9|CCDC68
     1  MTTVTVTTEI PPRDKMEDNS ALYESTSAHI IEETEYVKKI RTTLQKIRTQ MFKDEIRHDS
    61  TNHKLDAKHC GNLQQGSDSE MDPSCCSLDL LMKKIKGKDL QLLEMNKENE VLKIKLQASR
   121  EAGAAALRNV AQRLFENYQT QSEEVRKKQE DSKQLLQVNK LEKEQKLKQH VENLNQVAEK
   181  LEEKHSQITE LENLVQRMEK EKRTLLERKL SLENKLLQLK SSATYGKSCQ DLQREISILQ
   241  EQISHLQFVI HSQHQNLRSV IQEMEGLKNN LKEQDKRIEN LREKVNILEA QNKELKTQVA
   301  LSSETPRTKV SKAVSTSELK TEGVSPYLML IRLRK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC68 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.51
Highest tissue expression
31 nTPM

Expression across tissuesHPA

Tissue

  • placenta: 31 nTPM
  • small intestine: 23 nTPM
  • duodenum: 19 nTPM
  • colon: 18 nTPM
  • rectum: 17 nTPM
  • stomach: 14 nTPM

Single-cell type

  • somatotrophs: 167 nCPM
  • sertoli cells: 163 nCPM
  • salivary ionocytes: 118 nCPM
  • colonocytes: 116 nCPM
  • enterocytes: 114 nCPM
  • early spermatids: 97 nCPM

Immune cell

  • non-classical monocyte: 0.2 nTPM
  • basophil: 0.1 nTPM
  • intermediate monocyte: 0.1 nTPM
  • naive CD8 T-cell: 0.1 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM

Brain region

  • hypothalamus: 7.3 nTPM
  • thalamus: 6.8 nTPM
  • cerebral cortex: 5 nTPM
  • choroid plexus: 4.7 nTPM
  • midbrain: 4.7 nTPM
  • pons: 4.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CCDC68.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 53 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Recurrent spontaneous abortion

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.41
gnomAD pLI
0
gnomAD missense Z
-0.18
DepMap mean gene effect
0.14
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCDC68 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC68 as an antibody target. Whether an autoantibody or antibody against CCDC68 could matter depends on whether native CCDC68 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC68 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC68 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CCDC68. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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